Hypercortisolism induced by Cushing disease causes high morbidity and mortality. The treatment of choice is pituitary surgery, but it often fails to achieve cure, and other treatment modalities (radiotherapy, bilateral adrenalectomy) may therefore be required. If these treatments are not effective or while waiting for their results, hypercortisolism should be controlled with drugs. The classica...

cushing’s syndrome which is an uncommon but lethal disorder occurs due to many causes. the most common endogenous cause is cushing’s disease or pituitary cushing. the etiology of this disorder is an adenoma in the anterior pituitary. the most important point in the treatment of this disorder is differentiation between cushing’s disease (pituitary) and cushing’s syndrome (adrenal). we can differ...

PURPOSE To document the accuracy of CT and MR of the sella turcica for detecting adrenocorticotropic hormone-secreting adenomas in Cushing disease. METHODS The radiologic findings of the sella turcica prior to transsphenoidal surgery are reviewed in 141 patients who had biochemical evidence of pituitary-dependent Cushing disease. Axial thin-collimation CT scans with sagittal and coronal refor...

Introduction: Cushing disease is a rare entity, and among them, giant pituitary adenomas causing rarer. Here we present case of secondary to macroadenoma. Case report: A 41-year-old female with poorly controlled diabetes mellitus hypertension diagnosed for six months presented history unintentional weight loss, polyuria polydipsia the same duration. There was change in her facial appearance inc...

BACKGROUND Cushing syndrome (CS) is the result of extended exposure to excessive glucocorticoids from endogenous or exogenous sources. Traditionally, the most common cause of endogenous CS is a pituitary adenoma (Cushing disease). Less common causes are adrenocortical tumors and extrapituitary adrenocorticotropin-producing neoplasias. OBJECTIVES This review provides updated information regard...

Neurologic complications associated with inferior petrosal sinus sampling for adrenocorticotropic hormone in the diagnosis of Cushing syndrome are rare. Previously reported complications include brain stem infarction and pontine hemorrhage. We report a case of venous subarachnoid hemorrhage with subsequent acute obstructive hydrocephalus occurring during inferior petrosal sinus sampling for Cus...