The aim of the present study was to formulate and investigate the calcium alginate- (CA-) Neusilin US2 nanocomposite microbeads containing preconcentrate of aceclofenac sodium (ACF-Na) liquid microemulsion (L-ME) for enhancement of oral bioavailability. The preconcentrate L-ME is prepared by using Labrafac PG, Labrasol, and Span 80 as oil, surfactant, and cosurfactant, respectively. The solid C...

INTRODUCTION Punica granatum is apotent source of polyphenolic compounds with strong free radicals scavenging activity. The skin lightening effects of Punica granatum are assumed due to ellagic acid which acts by chelating copper at the active site of tyrosinase. AIM To explore a topical microemulsion (O/W) of pomegranate (Punica granatum) extract for its control on skin erythema and melanin....

Purpose: Diltiazem, a calcium ion cellular influx inhibitor is known for its limited and variable bioavailability. This study is intended to explore the benefits of microemulsion formulation as oral drug delivery system for immediate release to improve the bioavailability and efficacy of Diltiazem. Methods: Oil in water microemulsion was prepared using the simple water titration method. The opt...

A method is used for preparing gold NRs with aspect ratios ranging from 1.5 to 10 for which the surface plasmon absorption maxima are between 600 and 1300 nm. This method has been adapted from a previously published seed-mediated growth method (Jana et al. Adv. Mater. 2001, 13, 1389). The disadvantages and limitations of the earlier method (i.e., formation of noncylindrical NRs, φ-shaped partic...

502 What is MELC? Microemulsions are stable, isotropically clear solutions consisting of an oil (such as octane) and water stabilized by a surfactant and co-surfactant. To form such a mixture the interfacial tension between the oil and water has to be decreased by the addition of both a surfactant and a cosurfactant. Sodium dodecyl sulphate (SDS) is a common and widely used surfactant.1,2 Mediu...

The rationale of this study acquaint with improvement of sertraline hydrochloride (STH) solubility, formulation of STH nanoemulsion (NE) for intranasal delivery to achieve rapid onset of action and to omit first pass effect with enhanced bioavailability. STH nanoemulsion (NE) system was formulated consisting of capmul MCM as oil phase, tween 80 as surfactant and propylene glycol as cosurfactant...

Kinetin is a highly potent growth factor that is capable of delaying or preventing age-related changes of human skin fibroblasts. The purpose of this study was to develop and characterize topical kinetin-loaded emulsion gel and liposome gel formulations. Emulsion formulation was prepared using the spontaneous emulsification method. Pseudoternary phase diagram for oil/water (o/w) type emulsion w...

The utilization of self-microemulsifying premicroemulsion systems (SMEPMS) as templates for preparing poorly water-soluble compounds in the nanosized range represents a promising strategy. Fenofibrate was formulated with n-butyl L-lactate, Tween 80, and a number of cosurfactants (ethanol, 1-propanol, and PEG 600), diluted with the water phase (either water or saccharide solution) and then subje...

BACKGROUND The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations. METHODS Various microemulsion vehicles were prepared using isopropyl myristate as an oil phase, polyoxyethylated castor oil (Cremophor(®) EL) as a surfactant, and polyethylene glycol 400 as a cosurfactant. In the optimum microemulsion gel...

correspondence: Qi shen school of Pharmacy, shanghai Jiao Tong University, Dongchuan road 800, shanghai 200240, People’s republic of china Tel +86 21 3420 4049 Fax +86 21 3420 4049 email [email protected] Background: The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations. Methods: Various microemulsion veh...