The marked effects of cortisone on a disease such as rheumatoid arthritis,’ in which bacterial hypersensitivity is said to play a part, suggested to us that perhaps cortisone would alter the pathogenesis of tuberculosis, a disease in which bacterial hypersensitivity occurs as a prominent feature. The following report is an account of an experiment in which it was found that the administration o...

Studies of the influence of cortisone on the dynamics of influenza virus multiplication have suggested that cortisone may act to limit the interference with virus increase effected by autologous non-infective but hemagglutinating virus (1). An earlier investigation had adduced evidence for multiplici ty reactivation in the presence of cortisone of virus rendered non-infective (inactive) by mild...

cortex leading to the discovery of cortisone (Mason, Myers and Kendall, 1936; Wintersteiner and Pfiffner, 1936 ; Reichstein, 1936). The beneficial effect of pregnancy on rheumatoid arthritis was first observed by Hench in 1938 but the antirheumatic arthritic action of cortisone was established as late as 1949 by Hench, Kendall and their collaborators. Since then beneficial effect of cortisone h...

It may be appropriate to discuss in this Nobel Lecture three general aspects of cortisone and pituitary adrenocorticotropic hormone (ACTH): (1) the development of the theory which eventually led to the use of cortisone and ACTH in rheumat ic and cer ta in o ther condi t ions ; th i s I sha l l do in some detail, giving certain data not published heretofore; (2) the present status of cortisone a...

Cortisol and cortisone concentrations in serum and follicular fluid (FF) from women undergoing in-vitro fertilization (IVF) treatment were monitored. Four groups were included: group 1, women in their natural menstrual cycle having an endogenous mid-cycle surge of gonadotrophins; group 2, women in their natural menstrual cycle receiving human chorionic gonadotrophin (HCG) for ovulation inductio...

The effects of cortisone on the dietary induction and repression of serine dehydrase, ornithine transaminase, and tyrosine transaminase were studied. In rats pretreated with cortisone dietary induction was affected relatively little, but carbohydrate repression was largely eliminated. The effects of cortisone and phenobarbital on the dietary induction of serine dehydrase and ornithine transamin...

The effects of cortisone on the dietary induction and repression of serine dehydrase, ornithine transaminase, and tyrosine transaminase were studied. In rats pretreated with cortisone dietary induction was affected relatively little, but carbohydrate repression was largely eliminated. The effects of cortisone and phenobarbital on the dietary induction of serine dehydrase and ornithine transamin...

The effects of glycyrrhizin on the pituithry adrenal axis were studied. Isolated rat anterior pituitary glands were incubated with 14C-phenylalanine and biosynthetic activity of corticotropin in the pituitary was estimated. The rate of incorporation of radioactivity from 14C-phenylalanine into corticotropin fraction in the rat anterior pituitary was increased specifically by prior adrenalectomy...

In 1952 cortisone therapy was initiated in two patients with far advanced prostatic carcinoma.2 As part of the study of those patients, determinations were made of urinary 17-ketosteroid excretion before and during therapy with cortisone. Rather large increases in excretion of 17-ketosteroids were noted during the administration of high doses of cortisone in both patients. This unexpected findi...

Maternal serum cortisol has been suggested to be influenced by psychiatric morbidity, and may also influence fetal growth. However, several studies found equal cortisol levels in depressed and healthy pregnant women. Placental 11-β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) shields the fetus from maternal cortisol by conversion to cortisone, a function that may be compromised by maternal st...