a massive sequencing approach of a cDNA library, the whole set of Hox genes of the chondrichthyan, Scyliorhinus canicula. We have sequenced seven BAC clones that include all of the HoxA, HoxB and HoxD clusters. The transcriptomic data suggests that no HoxC genes have been maintained in this species. The expression of the posterior Hox genes was studied by insitu hybridization and showed that al...

Reliable measurements of effluent quality are important for different operational tasks such as process monitoring, online simulation, and advanced control in the wastewater treatment process (WWTP). A kernel principal component analysis (KPCA) and extreme learning machine (ELM) based ensemble soft sensing model for effluent quality prediction was proposed. KPCA was used to extract nonlinear fe...

Chromosomes must be highly compacted and organized within cells, but how this is achieved in vivo remains poorly understood. We report the use of chromosome conformation capture coupled with deep sequencing (Hi-C) to map the structure of bacterial chromosomes. Analysis of Hi-C data and polymer modeling indicates that the Caulobacter crescentus chromosome consists of multiple, largely independen...

The subsection entitled Performance in the presence of high collinearity on page 15 starts with the sentence “It is reasonable to assume that the presence of highly correlated covariates may complicate the identification of relevant predictors.” Two new covariates, which are linear combinations of existing covariates, are then added to simulated data which had N = 50 samples and p = 200 covaria...

Epidemiological studies of community populations are highly relevant to the process of setting national ambient air quality primary standards, as criteria for those standards are the protection of human populations against adverse effects on health. Nevertheless, because of the difficulties of performing adequate community population studies of a quality commensurate with the needs of standard ...

A review of recent research addressed two questions: how common are problems of substance abuse in traumatic brain injury (TBI), and to what extent does alcohol and other drug use mediate outcome? Studies showed alcohol intoxication present in one third to one half of hospitalizations; data for other drug intoxication were not available. Nearly two thirds of rehabilitation patients may have a h...

The arrangement and location of homologous DNA sequences within the genomes of equine herpesvirus type 1 (EHV-1) and EHV-3 were investigated by using Southern blot hybridization analyses conducted under stringent conditions. Recombinant plasmid libraries comprising 95 and 84% of the EHV-1 and EHV-3 genomes, respectively, were labeled with 32P-deoxynucleotides by nick translation and were used a...

High-level resistance to multiple drugs is often detected by directly sequencing uncloned polymerase chain reaction products (population-based sequencing). It is not known, however, if this method of identifying mutations gives an accurate picture of individual viral genomes. To determine how often multidrug-resistant isolates consist of clones containing every mutation present in the populatio...

This paper presents a method to predict the relative objective weighting scheme necessary to cause arbitrary members of a Pareto solution set to become optimal. First, a polynomial description of the Pareto set is constructed utilizing simulation and high performance computing. Then, using geometric relationships between the member of the Pareto set in question, the location of the utopia point...

The Hox cluster genes encode a family of transcriptions factors that contain the homeodomain and determine the anteroposterior positional values in a wide range of metazoan, from nematodes to vertebrates. The genomic organisation of these genes is colinear with their expression domains in development (Duboule and Dolle, 1989). In contrast, during axolotl limb regeneration (Gardiner et a1.1995) ...