Tuberculosis (TB), one of the top ten causes death globally induced by infection Mycobacterium tuberculosis (Mtb), remains a grave public health issue worldwide. With almost one-third world’s population getting infected Mtb, between 5% and 10% these individuals are predicted to develop active TB disease, which would not only result in severe tissue damage necrosis, but also pose serious threats...

The complete nucleotide sequence of ermA, the prototype macrolide-lincosamide-streptogramin B resistance gene from Staphylococcus aureus, has been determined. The sequence predicts a 243-amino-acid protein that is homologous to those specified by ermC, ermAM, and ermD, resistance determinants from Staphylococcus aureus, Streptococcus sanguis, and Bacillus licheniformis, respectively. The ermA t...

MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer. MiRNA function is most often achieved through binding to the 3'-untranslated region of the target protein coding gene. Mutation screening using massively-parallel sequencing of 712 miRNA genes in 86 ovarian cancer cases identified only...

Transcript levels do not faithfully predict protein levels, due to post-transcriptional regulation of gene expression mediated by RNA binding proteins (RBPs) and non-coding RNAs. We developed a multivariate linear regression model integrating RBP levels and predicted RBP-mRNA regulatory interactions from matched transcript and protein datasets. RBPs significantly improved the accuracy in predic...

related homeobox 1 gene, Prrx1, are up-regulated in the autopods of the bat wing compared to the bat hindlimb and mouse forelimb. Changes in the mRNA transcript abundance of several genes involved in retinoic acid (RA) synthesis, degradation and signaling were consistent with the down-regulation of the RA signaling pathway in the developing bat wing autopod. Signal from a microarray probe targe...

related homeobox 1 gene, Prrx1, are up-regulated in the autopods of the bat wing compared to the bat hindlimb and mouse forelimb. Changes in the mRNA transcript abundance of several genes involved in retinoic acid (RA) synthesis, degradation and signaling were consistent with the down-regulation of the RA signaling pathway in the developing bat wing autopod. Signal from a microarray probe targe...

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Bisphenol A (BPA) is a synthetic compound widely used in types of consumer goods and medical tools. It has been shown that BPA acts as an endocrine disruptor chemical casuing negative impact on reproductive functions. The present study used an in vitro approach to assess estrogenic transcriptional activity of BPA as a rapid and sensitive method. The cultured pieces of hepatic tissue of goldfish...

With CR-RT-PCR as primary approach we mapped the 5' and 3' transcript ends of all mitochondrial protein-coding genes in Arabidopsis thaliana. Almost all transcripts analyzed have single major 3' termini, while multiple 5' ends were found for several genes. Some of the identified 5' ends map within promoter motifs suggesting these ends to be derived from transcription initiation while the majori...