BACKGROUND Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide) (CS-PLGA) nanoparticles was investigated for intestinal delivery of exendin-4. METHODS AND RESULTS Nanoparticles were prepared using a modified water-oil...

Bone-like apatite coating of polymeric substrates by means of biomimetic process is a possible way to enhance the bone bonding ability of the materials. The created apatite layer is believed to have an ability to provide a favorable environment for osteoblasts or osteoprogenitor cells. The purpose of this study is to obtain bone-like apatite layer onto chitosan fiber mesh tissue engineering sca...

Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core...

The preparation of polyacrylonitrile (PAN) hollow fiber (HF) membranes has been carried out by dry-jet wet spinning. PAN HF membranes were coated with chitosan biopolymers 2 wt% by dip coating and further crosslinked by chemical reagents (Tri sodium polyphosphate). PAN HF (Virgin) and PAN/chitosan coated membrane were characterized by SEM and tested for water flux. Proteins Pepsin, Albumin, and...

In this paper, new sustained release microspheres with a surface coating of targeting moieties coating are presented. Bovine serum albumin (BSA) was used to prepare the microspheres loading with 5-fluorouracil (5-FU) by means of chemical crosslinking method and then the microspheres were coated with N-galactosylated chitosan by electrostatic interaction. The structure of coating layers on the s...

The effect of coating with irradiated Crab and Shrimp chitosan (CHIirr, Mv = 5.14 × 104) and un-irradiated Crab chitosan (CHIun, Mv = 2.61 × 105) on postharvest preservation of mango (Mangifera indica L.) fruit was studied. Irradiation at 100 kGy and 200 kGy of both Crab chitosan and Shrimp chitosan were used and the fruits were stored at 15°C ± 1°C and 85% relative humidity for 6 weeks. The ef...

Abstract Sapodilla fruit ( Manilkara zapota ) is one of the annual tropical plants that have a shelf life only 3-4 days at room temperature. One way to extend by coating. Chitosan has an excellent potential be applied as edible The addition essential oils, namely Vanilla and Betel, expected improve characteristics coating act antimicrobial antioxidant. This research was conducted using Chitosan...

Chitosan is a natural biopolymer that must be dissolved in an acid solution to activate its antimicrobial and eliciting properties. Among 15 acids tested, chitosan dissolved in 1% solutions of acetic, L-ascorbic, formic, L-glutamic, hydrochloric, lactic, maleic, malic, phosphorous, and succinic acid. To control gray mold, table grape berries were immersed for 10 s in these chitosan solutions th...

The objective of this work was to characterize the cinnamon oil nanocapsule that contained alginate-chitosan as coating agents. In this work, cinamonn oil loaded chitosan nanoparticles (CS-alginate NP-cinamonn) are prepared by a two-step process including oil/water emulsion and ionic gelation. In this study, cinamon as a core material was nanoencapsulated with chitosan alginate at a ratio of 1:...