Chronic immune thrombocytopenic purpura (CITP) is a diagnosis of exclusion that occurs either de novo or secondary to other underlying disorders. Chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) are now well-characterized causes of CITP. Between 6% and 15% of patients infected with HIV may develop thrombocytopenia. Patients with CITP with risk factors for HI...

Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. The estimated incidence is 100 cases per 1,000,000 patients, and half of the cases are seen in children. In children, the gender distribution is equal, whereas in adults, women are three times more likely to be affected than are men. ITP is defined as chronic if it lasts for longer than 6...

Immune mediated thrombocytopenia (ITP) is a common manifestation of autoimmune disease in children. Although patients often present with bruises, petechiae, and some mucosal bleeding, the incidence of life-threatening hemorrhage is rare (0.2-0.9%) but can be fatal when presenting in vital organs. A wide range of therapeutic regimens are currently in use, including observation alone, as the majo...

Acute myocardial infarction (AMI) in patients with immune thrombocytopenic purpura (ITP) is rare. We describe a case of AMI in patient with ITP. An 81-year-old woman presented with acute inferoposterior MI with low platelet count on admission (34,000/µl). Coronary angiography revealed significant mid right coronary artery (RCA) stenosis with thrombus, subsequently underwent successful percutane...

Hepatitis A is common in children and usually is a self-limiting disease. Although extrahepatic and hematological immune manifestations following acute hepatitis A virus (HAV) infection have rarely been reported, they are frequently observed in other viral hepatitis. In this paper, we report the case of a 3-year-old girl who developed immune thrombocytopenic purpura (ITP) and hemolytic anemia a...

Introduction Severe acute kidney injury (AKI) and chronic kidney disease (CKD) are considered to be uncommon in patients with acquired thrombotic thrombocytopenic purpura. However, a recent case series from a tertiary care hospital indicated that 54 (59%) of 92 patients with thrombotic thrombocytopenic purpura presented with AKI; 14 (15%) required dialysis; and 12 (22%) of the 54 patients had C...

Because of the rareness reports about immune thrombocytopenic purpura patients undergoing cardiac surgery, there is no sufficient knowledge perioperative strategies. In this article, we report a 42-year-old female patient with severe mitral regurgitation and large right atrial thrombus, in whom thrombocytopenia had disappeared after valve replacement thrombectomy from atrium. Large thrombi shou...

Severe thrombocytopenia is a cause of morbidity and mortality for patients with COVID-19 infection. The common causes in these are; sepsis, drug-associated, disseminated intravascular coagulation (DIC), heparin-associated (HIT), microangiopathic hemolytic anemia (MAHA). Recently, cases infection-associated Immune thrombocytopenic purpura (ITP) have been reported the literature. In our study, we...

BACKGROUND Corticosteroid sparing is required in 15% to 40% of adults with persistent or chronic primary immune thrombocytopenic purpura (ITP). Herein, the efficacy of immunomodulatory drugs (dapsone, interferon alpha, danazol, and hydroxychloroquine as second-third-line therapies in ITP is investigated. METHODS MEDLINE was searched for studies that included patients with persistent or chroni...