نتایج جستجو برای: chou talalay method

تعداد نتایج: 1631007  

Journal: :T'oung Pao 1915

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Chelsea Bolyard Ji Young Yoo Pin-Yi Wang Uksha Saini Kellie S Rath Timothy P Cripe Jianying Zhang Karuppaiyah Selvendiran Balveen Kaur

PURPOSE Novel therapeutic regimens are needed to improve dismal outcomes associated with late-stage ovarian cancer. Oncolytic viruses are currently being tested in patients with ovarian cancer. Here, we tested the therapeutic efficacy of combining doxorubicin with 34.5ENVE, an oncolytic herpes simplex virus transcriptionally driven by a modified stem cell-specific nestin promoter, and encoding ...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Ryuichi Kanai Hiroaki Wakimoto Robert L Martuza Samuel D Rabkin

PURPOSE To develop a new oncolytic herpes simplex virus (oHSV) for glioblastoma (GBM) therapy that will be effective in glioblastoma stem cells (GSC), an important and untargeted component of GBM. One approach to enhance oHSV efficacy is by combination with other therapeutic modalities. EXPERIMENTAL DESIGN MG18L, containing a U(S)3 deletion and an inactivating LacZ insertion in U(L)39, was co...

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Journal: :Clinical Infectious Diseases 2018

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2011
Ryuichi Kanai Hiroaki Wakimoto Robert L. Martuza Samuel D. Rabkin

Purpose: To develop a new oncolytic herpes simplex virus (oHSV) for glioblastoma (GBM) therapy that will be effective in glioblastoma stem cells (GSC), an important and untargeted component of GBM. One approach to enhance oHSV efficacy is by combination with other therapeutic modalities. Experimental Design: MG18L, containing a US3 deletion and an inactivating LacZ insertion in UL39, was constr...

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Journal: :Acta poloniae pharmaceutica 2011
Małgorzata Milczarek Irena Misiewicz-Krzemińska Katarzyna Lubelska Katarzyna Wiktorska

The isothiocyanates present in the cruciferous plants were proved to have the antiproliferative and cytotoxic effect on cancer cell lines. Natural compounds in combination with chemotherapy agents enhance anticancer activities of drugs and reduce their toxicity. The aim of the presented study was to determine an effect of isothiocyanates and 5-fluorouracil used alone or in combination (in seque...

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Journal: :International journal of oncology 2015
Mathias Füller Miriam Klein Eva Schmidt Christian Rohde Stefanie Göllner Isabell Schulze Jiang Qianli Wolfgang E Berdel Bayram Edemir Carsten Müller-Tidow Petra Tschanter

The DNA methyltransferase (DNMT) inhibitory drugs such as 5-azacytidine induce DNA hypomethylation by inhibiting DNA methyltransferases. While clinically effective, DNMT inhibitors are not curative. A combination with cytotoxic drugs might be beneficial, but this is largely unexplored. In the present study, we analyzed potential synergisms between cytotoxic drugs and 5-azacytidine in acute myel...

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2006
Sava Krstić Ching-Tsun Chou Jim Grundy

We give complete mathematial foundations for the method, recently developed by Chou, Mannava, and Park, for verifying safety properties of cache coherence protocols. The method employs a specific form of counterexample-guided abstraction refinement and is originally described on worked-out examples of the German and FLASH protocols. We describe and prove the method at an abstract level, thus es...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Shu-Fu Lin Sizhi Paul Gao Daniel L Price Sen Li Ting-Chao Chou Paramjeet Singh Yu-Yao Huang Yuman Fong Richard J Wong

PURPOSE Novel therapeutic regimens are needed to improve the dismal outcomes of patients with anaplastic thyroid cancer (ATC). Oncolytic herpes simplex virus have shown promising activity against human ATC. We studied the application of oncolytic herpes simplex virus (G207 and NV1023) in combination with currently used chemotherapeutic drugs (paclitaxel and doxorubicin) for the treatment of ATC...

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Journal: :Molecular cancer therapeutics 2005
Alexandre Bozec Patricia Formento Joseph Ciccolini Raphaëlle Fanciullino Laetitia Padovani Xavier Murraciole Jean-Louis Fischel Gerard Milano

Recent studies suggest the possibility of a direct antiangiogenic effect of anti-epidermal growth factor receptor (EGFR) drugs due to the presence of EGFR on endothelial cells. The aim of this study was to analyze the direct effect on endothelial cells of associating EGFR targeting, vascular endothelial growth factor receptor (VEGFR)-2 targeting, and irradiation. We examined both the cytotoxic ...

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