Microfluidic deterministic lateral displacement (DLD) arrays have been applied for fractionation and analysis of cells in quantities of ~100 μL of blood, with processing of larger quantities limited by clogging in the chip. In this paper, we (i) demonstrate that this clogging phenomenon is due to conventional platelet-driven clot formation, (ii) identify and inhibit the two dominant biological ...

CHIP (Carboxy terminus of Hsc70 Interacting Protein) is an E3 ubiquitin ligase that can induce ubiquitination and degradation of several oncogenic proteins. The expression of CHIP is frequently lower in human breast cancer than in normal breast tissue. However, the expression and role of CHIP in the canine mammary gland tumor (CMGT) remain unclear. We investigated the potential correlation betw...

technology with through-silicon vias and low-volume leadfree interconnections K. Sakuma P. S. Andry C. K. Tsang S. L. Wright B. Dang C. S. Patel B. C. Webb J. Maria E. J. Sprogis S. K. Kang R. J. Polastre R. R. Horton J. U. Knickerbocker Three-dimensional (3D) integration using through-silicon vias (TSVs) and low-volume lead-free solder interconnects allows the formation of high signal bandwidt...

The measurement of single poly(ethylene glycol) (PEG) molecules interacting with individual bilayer lipid membrane-bound ion channels is presented. Measurements were performed within a polymer microfluidic system including an open-well bilayer lipid membrane formation site, integrated Ag/AgCl reference electrodes for on-chip electrical measurements, and multiple microchannels for independent io...

This paper presents investigations on turning Ti–6Al–4V alloy withmulti-layer coated inserts. Turning of Ti–6Al–4V using uncoated, TiAlN coated, and TiAlN + cBN coated single and multi-layer coated tungsten carbide inserts is conducted, forces and tool wear aremeasured. 3D finite elementmodelling is utilized to predict chip formation, forces, temperatures and tool wear on these inserts. Modifie...

as technology scales deep into the nanometer regime, on-chip communication becomes more susceptible to transient noise sources, such as crosstalk, external radiation, and spurious voltage spikes. the network on chip s modularity and reusability has brought about the use of error control methods to address transient errors in network on chip links.in this work, we design a fault tolerance router...

Abstract Metal working fluids are used in machining processes of many hard-to-cut materials to increase tool life and productivity. Thereby, the metal act on thermal mechanical loads tool. The changing can mostly be attributed friction between rake face chip changes formation, e.g., contact length chip. However, analyzing those effects is challenging, since a detailed look at formation process ...

we design and simulate a five-port optical router, which is composed of twenty mach-zehnder-based switching elements and twelve waveguide crossings for use in integrated photonic interconnection networks. we simulated and analyzed the operation of the proposed optical router from the aspects of insertion loss, power budget, q-factor and the minimum bit error ratio by use of optisystem simulator...

Based on the variation of actual cutting depth during grinding process, a 3D finite element simulation model for nickel-based superalloy GH4169 with single abrasive was initially constructed. Then, morphological evolution chips process studied. In addition, effect and speed chip morphology segmentation frequency were investigated. Finally, experimental results same test parameters verify result...