The crude incidence of prostate cancer in the European Union is 78.9/100 000 men/year. It is the most common cancer in men. The mortality in the EU is 30.6/100 000 men/year. Subclinical prostate cancer is present in the majority of men. Screening of healthy men using prostate-specific antigen (PSA) testing increases the incidence (overdiagnosis). The effect of screening and early intervention o...

An impaired fibrinolytic function due to elevated plasma levels of plasminogen activator inhibitor (PAI)-1 activity or tissue plasminogen activator (tPA) antigen is correlated with the development of myocardial infarction (MI) in patients with manifest coronary heart disease. Recently, methods for determining the specific tPA/inhibitor complexes constituting tPA antigen in plasma have become av...

Oakley, Warrack & Clarke (1947) demonstrated the existence in culture filtrates of various strains of Clostridium oedematiens of six antigens, designated as ac, P, y, 8, e and 4. The ac-antigen is produced by both type A and type B strains and is the main lethal agent in Cl. oedematien8 toxic filtrates. Its biochemical action is unknown, but one of its physiological effects is that of a capilla...

We have investigated the feasibility of using human autoimmune antibodies to isolate and characterize specific nuclear ribonucleoprotein (nRNP) complexes. High titers of anti-nRNP antibodies occur in a syndrome called mixed connective tissue disease. IgG antibodies from two mixed connective tissue disease patients were used to construct affinity columns to isolate the antigenic complexes from r...

Human infection with Cryptosporidium parvum usually elicits characteristic immunoglobulin G (IgG), IgA, and IgM antibody responses against two sporozoite surface antigens with apparent molecular masses of approximately 27 and 17 kDa. We have determined that these two antigens are actually complex families of related antigens. We have developed two new enzyme-linked immunosorbent assays (ELISAs)...

Mite antigen has been suggested to play important roles in the onset and/or development of atopic dermatitis, and mite antigen-induced dermatitis models appear beneficial for the basic study of atopic dermatitis. In the present study therefore, we attempted to establish an allergic dermatitis model in mice using Dermatophagoides farinae crude extract as an antigen. Mite antigen solution at a co...

Objective(s) Leishmania can lead to a broad spectrum of diseases, collectively known as leishmaniasis. The A2 gene/ protein family could be one of the most eligible candidate factors of virulence in visceral leishmaniasis (VL). The previous results confirmed that in Leishmania infantum, several A2 proteins are abundantly expressed by the amastigote, but not the promastigote stage. As there are...

BACKGROUND Echinococcosis is a zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus. Several native and recombinant antigens, derived from different stages of E. granulosus life cycle, have been used for vaccine trials. In vitro reared adult worms are good candidates for vaccination as they do not produce fertile egg/s and do not have any risk of contamination for re...