(Y 2u Globulin is a protein synthesized in the liver, secreted into the serum, and excreted in the urine of mature male rats. The effects of androgens and estrogens on the level of the messenger RNA coding for this male rat hepatic protein have been investigated. Castrated male rats have reduced levels of (Y 2u globulin in serum and liver cytosol, as measured by a radial immunodiffusion assay. ...

Employing diisopropanolnitrosamine (DIPN)-induced rat thyroid tumors as an experimental model, the possible role of androgen in thyroid carcinogenesis was examined. The rate of tumer induction was higher in male than female rats. In male rats, at 15 to 20 weeks after the final DIPN iajection, the thyroid glands were remarkably enlarged and were being replaced by carcinoma tissues. Castration of...

Welfare concerns are growing regarding surgical castration (SC) in pets, necessitating the need for non-surgical alternatives. Administration of vaccines against gonadotropins releasing hormone (GnRH) have been reported as alternative to SC. This study determined the effect of surgical and immunological castrations (IC) on complete blood counts, plasma testosterone (T), luteinizing hormone (LH)...

BACKGROUND Sperm binding proteins and their C-terminal peptides of the Sperm Associated Antigen 11 (SPAG11) family were found to play an important role in epididymal innate immunity in addition to their role in sperm maturation. However, the expression of Spag11 transcripts in rodents is not well documented. METHODS Computational analysis was employed to identify novel Spag11 isoforms in the ...

BACKGROUND AND PURPOSE A number of studies indicate that the female gonadal hormone, estrogen, confers protection against cerebrovascular disorders such as stroke. One postulated mechanism for these effects of estrogen is an action on the enzyme endothelial nitric oxide synthase (eNOS), which produces the vasodilatory molecule NO. We have investigated the hypothesis that estrogen increases expr...

Antibodies to native DNA and to polyadenylic acid (Poly A) occur spontaneously and undergo a regulated switch from IgM to IgG during the course of autoimmune disease in NZB/NZW F(1) (B/W) mice. B/W females have higher titers and earlier commitment to 7S antibodies to DNA and Poly A, whereas B/W males bind DNA and Poly A primarily by 19S antibodies. We have performed castration experiments to de...

Gametocyte sex ratio of the malaria parasite Plasmodium mexicanum is variable in its host, the western fence lizard (Sceloporus occidentalis), both among infections and within infections over time. We sought to determine the effect of host physiological quality on the gametocyte sex ratio in experimentally induced infections of P. mexicanum. Adult male lizards were assigned to 4 treatment group...

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau castrated rats than in controls, and testosterone restored these decreases (each P<0.05). The expression levels of cyclooxygenase-2 (COX-2), prostacyclin synthase (PTGIS or PGIS), endothelial nitric oxide synthase (eNOS) and phospho-eNOS were reduced in castrated rats compared with contr...

The tumor-inhibitory effect of pyruvalclehyde bis(thiosemicarbazone) was greater on 6 tumors carried in male mice and rats than in females. The effect of the compound on Walker 256 in castrated male rats was similar to that seen in females. In castrated males, the antitumor activity was less than that in normal males. The injection of estradici in such castrated males did not alter the effect. ...

OBJECTIVE To compare the efficacy of early versus delayed surgical castration on prolonging survival and further to investigate the anticancer effect and potential value of targeting androgen in the therapeutic intervention of bladder cancer. MATERIALS AND METHODS N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was used to induce bladder cancer in male mice. Mice were randomly divided into three...