PURPOSE To evaluate MYOC (myocilin) gene expression at the RNA level in normal intact human eyes and optic nerve using in situ hybridization. METHODS Normal human eyes and optic nerves from donors 62 to 83 years of age with no history of glaucoma were fixed, embedded in paraffin, and sectioned. Sections were hybridized with (35)S-labeled sense and antisense riboprobes derived from a full-leng...

The hydraulic pressure is one of the most important factors in the design of pressure intake tunnels. Since the surrounding media cannot usually resist the high internal pressure of these tunnels, they are usually finished with an adequate lining mostly of reinforced concrete, which is an interaction problem between water, soil or rock and concrete lining. Although reinforcing the concrete lini...

There are several methods for analysing the behaviour of underground structures under different loading conditions. Most of these methods have many simplifications; therefore, in some cases, the results are too conservative and a very high safety factor, usually of more than 2 is needed. On the other hand, for stability analysis and the designing of support systems, these methods consider segme...

The induced cracks on the concrete lining of the intake pressure tunnels may cause the water seep into the surrounding media leading to develop a hydro pressure on the external surface of the lining. In the common design practice, the lining can be designed to tolerate with this pressure using the Schleiss method. However, when the tunnel is constructed above the underground water, the seepage ...

According to the wide application of segmental lining in mechanized tunneling, recognizing the behavior of segmental lining joints is important in tunnels designing. In the structural analysis of the tunnel segmental lining, segmental joints can be considered as elastic joints, and their stiffness characteristics are affected by the rotational, shear, and axial stiffness. The purpose of this wo...