نتایج جستجو برای: caco 2
تعداد نتایج: 2525618 فیلتر نتایج به سال:
Human organic anion transporting polypeptide OATP-B (OATP2B1) is a pH-sensitive transporter expressed in the apical membranes of small intestinal epithelial cells. In this study, we have examined the contribution of OATP-B to the uptake of [3H]estrone-3-sulfate in Caco-2 cells in comparison with those of its homologs OATP-D (OATP3A1) and OATP-E (OATP4A1). Immunocytochemical study revealed that ...
Cyclooxygenase-2 (COX-2) was recently reported (M. Tsujii and R. N. DuBois, Cell, 83: 493-501, 1995) to affect the metastatic potential of cells. Previous studies (M. Fukuda, Cancer Res., 56: 2237-2244, 1996) indicated that sialyl Lewis antigen expression is correlated with hematogenous metastasis of colon cancer. In the present study, we investigated the interaction between COX-2 activity, exp...
these tripeptides was studied by using monolayercultured human intestinaJ Caco-2 cells which express rnany enterocyte-Iike functions including the peptide transporter(PepTl)-mediated transport system. ValPro-Pro, an ACE-inhibitors peptide from fermented milk, was used as a model tripeptide. A significant amount of intact Val-Pro-Pro was transported across the Caco-2 cel) monolayer. This transpo...
Introduction: Efforts are made to identify the new potential components such as anticancer drugs. Medicinal plants belonging to Euphorbia genus are widely studied with promising effects. The current study aimed at investigating the effect of ethanolic extract of the root of E. tehranica, grown in Iran, on Caco-2 human colorectal cancer cell-line. Methods: The Caco-2 cells were treated with dif...
Decay-accelerating factor (DAF) has been reported to be a cellular receptor for several enteroviruses. Buffalo green monkey kidney (BGMK) cells expressing human DAF (BGMK-hDAF cells) showed increased susceptibility and sensitivity to several types of enteroviruses compared to wild-type BGMK cells. When 17 frozen positive clinical samples were tested, BGMK cells detected 8 and BGMK-hDAF cells de...
In arid and semi-arid lands, people eats many kinds of spices. Capsaicin is one effect active component of spices. Previously we demonstrated that capsaicin induced tight junction (TJ) opening in human intestinal Caco-2 cells. We showed that the increase of TJ permeability was involved in actin polymerization. However the underlying mechanisms are unclear. The major aims of this study were to d...
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