This article provides an overview of the main controversies in a number of key areas of breast cancer management. Relevant studies that have contributed to guide the treatment of this heterogeneous disease in the field of breast screening, surgery, chemotherapy and radiotherapy are highlighted. Mammography and ultrasound are the main methods of breast screening. MRI and tomosynthesis are emergi...

Breast cancer is the most common type of cancer among women with an incidence rate of 13% worldwide (Bray et al., 2004; Boyle et al., 2005; Héry et al., 2008). Whole breast radiotherapy, which is widely used after breast-conserving surgery, has been shown to reduce the risk of loco-regional recurrence of breast cancer by approximately 70% and to be as effective as radical mastectomy (Fisher et ...

Background: Radiotherapy (RT) is recommended to all patients undergoing Breast Conserving Surgery (BCS). Two strategies can be applied to irradiation, External Beam RT (EBRT) in addition, Intraoperative Radiation Therapy (IORT). The aim of this study was to introduce a protein biomarker panel related to molecular function of IORT. Materials and Methods: Six Breast Cancer (BC) patients as a pilo...

background: we aimed to compare field-in-field technique (fif) with conformal tangential field radiotherapy (crt) in terms of dosimetric benefits for early stage breast cancer radiotherapy. materials and methods: twenty consecutive left-side breast cancer patients who underwent breast-conserving surgery were included to the study. for each patient, two different treatment plans were created for...

PURPOSE The objective of this study was to investigate the influence of radiotherapy on the cosmetic outcome after immediate breast reconstruction using an absorbable mesh in breast cancer. METHODS From July 2008 to July 2009, 35 breast cancer patients who received immediate breast reconstruction with absorbable mesh insertion at the time of breast conserving surgery followed by radiotherapy ...

Over one-quarter of a million cases of breast cancer are diagnosed in the United States each year, many of which are early stage.The radiotherapeutic options after breast-conserving surgery in early-stage breast cancer are evolving quickly, with a focus on minimizing treatment volume, toxicity, and treatment duration. One such emerging option is intraoperative radiotherapy (IORT), administered ...

Several large prospective and retrospective studies have demonstrated excellent long-term outcomes after breast conservative treatment with radiation in invasive breast cancer. Breast-conserving surgery (BCS) followed by radiotherapy (RT) is an accepted management strategy for patients with DCIS. Adding radiation treatment after conservative surgery enables to reduce, without any significant ri...

Background: Breast-conserving surgery (BCS) followed by radiotherapy (RT) is the standard of care for women with breast cancer. Evidence shows that RT dose to the heart can result in ischemic heart disease. In this study we compared 3 different RT techniques were for heart, left anterior descending coronary artery (LAD) and lung doses in left breast cancer patients after breast-conserving surge...

We thank the editors for giving us an opportunity to respond to this letter. We also thank the authors of the letter for their interest in our article and their kind comments. The authors seem to imply that oncoplastic breast surgery (OBS) is restricted to breast-conserving surgery for large tumours. However, OBS also refers to the techniques of skin-sparing mastectomy and immediate reconstruct...