نتایج جستجو برای: biomarker panel

تعداد نتایج: 139714  

2017
Joong Kyong Ahn Jungyeon Kim Jiwon Hwang Juhwan Song Kyoung Heon Kim Hoon-Suk Cha

Diagnosing Behcet's disease (BD) is challenging because of the lack of a diagnostic biomarker. The purposes of this study were to investigate distinctive metabolic changes in urine samples of BD patients and to identify urinary metabolic biomarkers for diagnosis of BD using gas chromatography/time-of-flight-mass spectrometry (GC/TOF-MS). Metabolomic profiling of urine samples from 44 BD patient...

2017
Francesca Pirini Sassan Noazin Martha H. Jahuira-Arias Sebastian Rodriguez-Torres Leah Friess Christina Michailidi Jaime Cok Juan Combe Gloria Vargas William Prado Ethan Soudry Jimena Pérez Tikki Yudin Andrea Mancinelli Helen Unger Carmen Ili-Gangas Priscilla Brebi-Mieville Douglas E. Berg Masamichi Hayashi David Sidransky Robert H. Gilman Rafael Guerrero-Preston

Clinically useful molecular tools to triage gastric cancer patients are not currently available. We aimed to develop a molecular tool to predict gastric cancer risk in endoscopy-driven biopsies obtained from high-risk gastric cancer clinics in low resource settings.We discovered and validated a DNA methylation biomarker panel in endoscopic samples obtained from 362 patients seen between 2004 an...

2006
B. E. Gilliam A. K. Chauhan J. M. Low T. L. Moore Brooke E. Gilliam Anil K. Chauhan

Objective To evaluate in juvenile idiopathic arthritis (JIA) patients a biomarker panel of anti-cyclic citrullinated peptide (anti-CCP) antibodies, cartilage oligomeric matrix protein (COMP), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), IgM rheumatoid factor (RF), IgG RF, and IgA RF and compare to the presence of joint erosions (JE), joint space narrowing (JSN), and synovitis...

Journal: :The American journal of cardiology 2016
Vincent E Friedewald Peter H Jones Preston Mason Robert Roberts Howard Weintraub

Despite several decades of research about triglycerides and atherosclerotic cardiovascular disease, controversy still surrounds the question whether triglycerides are more than a biomarker and play a direct causative role in atherogenesis. In this Editor’s Roundtable, a panel of leading lipid experts was invited to address this question and several closely related issues about triglycerides, in...

2016
Janice M. Leung Virginia Chen Zsuzsanna Hollander Darlene Dai Scott J. Tebbutt Shawn D. Aaron Kathy L. Vandemheen Stephen I. Rennard J. Mark FitzGerald Prescott G. Woodruff Stephen C. Lazarus John E. Connett Harvey O. Coxson Bruce Miller Christoph Borchers Bruce M. McManus Raymond T. Ng Don D. Sin

BACKGROUND Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in considerable morbidity and mortality. However, there are no objective biomarkers to diagnose AECOPD. METHODS We used multiple reaction monitoring mass spectrometry to quantify 129 distinct proteins in plasma samples from patients with COPD. This analytical approach was first performed in a biomarker coh...

Journal: :Archives of neurology 2012
James D Doecke Simon M Laws Noel G Faux William Wilson Samantha C Burnham Chiou-Peng Lam Alinda Mondal Justin Bedo Ashley I Bush Belinda Brown Karl De Ruyck Kathryn A Ellis Christopher Fowler Veer B Gupta Richard Head S Lance Macaulay Kelly Pertile Christopher C Rowe Alan Rembach Mark Rodrigues Rebecca Rumble Cassandra Szoeke Kevin Taddei Tania Taddei Brett Trounson David Ames Colin L Masters Ralph N Martins

OBJECTIVE To identify plasma biomarkers for the diagnosis of Alzheimer disease (AD). DESIGN Baseline plasma screening of 151 multiplexed analytes combined with targeted biomarker and clinical pathology data. SETTING General community-based, prospective, longitudinal study of aging. PARTICIPANTS A total of 754 healthy individuals serving as controls and 207 participants with AD from the Au...

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