Tyrosinase (EC 1.14.18.1) plays an indispensable role in the rate-limiting steps of melanin biosynthesis, and its uncontrolled activity may result various diseases, such as albinism, melanoma, freckles, etc. The inhibition tyrosinase provide a useful efficient strategy to treat hyperpigmentation disorders. However, widely used inhibitors, like ?-arbutin, hydroquinone, kojic acid, have many shor...