UNLABELLED Biliary atresia is a rapidly progressive obstructive cholangiopathy of infants. Mechanistic studies in the mouse model of Rhesus rotavirus (RRV)-induced biliary atresia have linked the importance of effector lymphocytes to the pathogenesis of extrahepatic bile duct (EHBD) injury and obstruction in experimental biliary atresia; however, studies of the progressive liver injury have bee...

The state of awaiting liver transplantation causes cognitive uncertainty for a patient [1]. Most children undergoing liver transplantation are those with biliary atresia, and most liver transplants to a child are carried out by a donation from their parents in Japan [2,3]. The ambiguous nature of biliary atresia and the possibility of living donor liver transplantation (LDLT) cause suffering to...

Mowat, A. P., Psacharopoulos, H. D., and Williams, R. (1976). Archives of Disease in Childhood, 51, 763. Extrahepatic biliary atresia versus neonatal hepatitis: review of 137 prospectively investigated infants. In a prospective regional survey of neonatal hepatitis syndrome 32 infants had extrahepatic biliary atresia (EHBA) and 103 had hepatitis. No cause for the lesion was found in infants wit...

background: neonatal cholestasis is an important infant’s diseases of liver and biliary, they are wide range of situation including; idiopathic neonatal hepatitis, extrahepatic biliary tract atresia, choledochal cysts and infectious diseases. lack of early diagnosis of the disease can be followed by irreparably complications. the aim of this study was determination the histopathological causes ...

tion. There have also been significant advances in the This commentary by the late Alex P. Mowat reflects his management of complications of chronic cholestasis extensive knowledge and experience in pediatric liver disand in some complications of cirrhosis. We have reason ease; its genesis reflects his commitment to education as well as his personal qualities. Dr. Mowat had presented an to cong...

Biliary atresia is the most common indication for liver transplantation (OLT) in children. We present our experience with OLT as a treatment for end-stage liver disease in children with biliary atresia. We performed a retrospective review of 20 biliary atresia patients (11 male, 9 female patients; mean age, 21.4 months; range, 6 to 84 months) who had undergone OLT. Mean preoperative weight and ...

OBJECTIVE To assess the feasibility of screening for cholestatic hepatobiliary disease and extrahepatic biliary atresia by using tandem mass spectrometry to measure conjugated bile acids in dried blood spots obtained from newborn infants at 7-10 days of age for the Guthrie test. SETTING Three tertiary referral clinics and regional neonatal screening laboratories. DESIGN Unused blood spots f...