embryogenesis. We extended this analysis to other Hox-Exd, or Hox-Hox interactions, revealing specific spatial and temporal dynamics during embryogenesis. Altogether, these results show that the BiFC is a highly sensitive method for analysing protein– protein interactions in the living drosophila embryo. Based on the BiFC approach, we established two genetic strategies to find novel cofactors o...

The penetration of plug-in electric vehicles (PEV) into nearfuture traffic and power infrastructure is expected to be large enough to have a serious impact on the grid. If each PEV arrives at home and charges immediately, the distribution network can incur in serious problems. Therefore, the charging process of the PEVs has to be coordinated, on the basis of the grid capabilities, generation an...

Two structures in the all-particle energy spectrum of cosmic rays, the knee at 4 PeV and the second knee around 400 PeV are proposed to be explained by a phenomenological model, the poly-gonato model, connecting direct and indirect measurements. Within this approach the knee is caused by a successive cut-off of the flux for individual elements starting with protons at 4.5 PeV. The second knee i...

There is considerable evidence to support the existence of dimers of class A G-protein-coupled receptors, including the histamine H1 receptor (H1R) (Bakker et al, 2004), although the functional significance of these dimers remains unclear. We have used bimolecular fluorescence complementation (BiFC) in combination with fluorescence correlation spectroscopy (FCS) to selectively monitor histamine...

embryogenesis. We extended this analysis to other Hox-Exd, or Hox-Hox interactions, revealing specific spatial and temporal dynamics during embryogenesis. Altogether, these results show that the BiFC is a highly sensitive method for analysing protein– protein interactions in the living drosophila embryo. Based on the BiFC approach, we established two genetic strategies to find novel cofactors o...

Bimolecular fluorescence complementation (BiFC) analysis enables direct visualization of protein interactions and modifications in living cells. It is based on the facilitated association of two nonfluorescent fragments of a fluorescent protein fused to putative interaction partners. The intrinsic fluorescence of the active complex enables detection of protein interactions with high sensitivity...

The JIL-1 kinase localizes specifically to euchromatin interband regions of polytene chromosomes and is the kinase responsible for histone H3S10 phosphorylation at interphase. Genetic interaction assays with strong JIL-1 hypomorphic loss-of-function alleles have demonstrated that the JIL-1 protein can counterbalance the effect of the major heterochromatin components on position-effect variegati...

The observation of two PeV-scale neutrino events reported by Ice Cube allows one to place constraints on Lorentz invariance violation (LIV) in the neutrino sector. After first arguing that at least one of the PeV IceCube events was of extragalactic origin, I derive an upper limit for the difference between putative superluminal neutrino and electron velocities of 6 5:6 10 19 in units where c 1⁄...

Next-generation power grids will likely enable concurrent service for residences and plug-in electric vehicles (PEVs). While the residence power demand profile is known and thus can be considered inelastic, the PEVs’ power demand is only known after random PEVs’ arrivals. PEV charging scheduling aims at minimizing the potential impact of the massive integration of PEVs into power grids to save ...

Characterization of a group of dominant second chromosome suppressor of position-effect variegation (PEV) (Su(var)) mutants has revealed a variety of interesting properties, including: maternal-effect suppression of PEV, homozygous lethality or semilethality and male-specific hemizygous lethality, female infecundity, acute sensitivity to the amount of heterochromatin in the cell and sensitivity...