OBJECTIVE Atherosclerotic lesions are associated with the accumulation of reactive aldehydes derived from oxidized lipids. Although inhibition of aldehyde metabolism has been shown to exacerbate atherosclerosis and enhance the accumulation of aldehyde-modified proteins in atherosclerotic plaques, no therapeutic interventions have been devised to prevent aldehyde accumulation in atherosclerotic ...

PURPOSE When performing coronary angiography (CAG), diagnostic catheter intubation to the ostium can cause damping of the pressure tracing. The aim of this study was to determine the predictors of atherosclerotic ostial stenosis in patients showing pressure damping during CAG. MATERIALS AND METHODS In total, 2926 patients who underwent diagnostic CAG were screened in this study. Pressure damp...

The major cause for plaque instability in atherosclerotic disease is neoangiogenic revascularization, but the factors controlling this process remain only partly understood. Hedgehog (HH) is a morphogen with important functions in revascularization, but its function in human healthy vessel biology as well as in atherosclerotic plaques has not been well investigated. Hence, we determined the sta...

Noninvasive cardiovascular imaging could lead to the early detection and timely treatment of complex atherosclerotic lesions responsible for major cardiovascular events. Recent investigations have suggested that optical coherence tomography (OCT) is an ideal diagnostic tool due to the high resolution this technology achieves in discriminating the different features of atherosclerotic lesions ba...

Intracranial atherosclerotic disease is normally detected by hemodynamically relevant intracranial stenosis using luminography-based methods. However, from the extracranial study, it is well known that lumen diameter can be maintained due to remodeling of the arteries in spite of wall thickening (Glagov et al., 1987), suggesting conventional luminography-based methods might underestimate athero...

Esterification of cholesterol with [l-C]palmityl-CoA by an atherosclerotic cell-free homogenate was approximately 16-50-fold greater than that by a normal cell-free homogenate for a given amount of protein in the homogenate. This difference was due to hyperactivity of the cholesterol-esterifying system in the atherosclerotic cell-free homogenate rather than to depletion of radioactive palmityl-...

BACKGROUND Soft tissue defects of the lateral malleolus (LM) and Achilles tendon pose difficult reconstructive problems due to the bony prominence and limited local tissue available. The objectives were to study the anatomical landmarks of the lateral calcaneal artery (LCA) and patency of LCA in atherosclerotic patients. METHODS Part I: Thirty-four cadaveric feet were dissected to identify th...

Computational assessment of atherosclerotic plaque components in MR images Evaluation of the composition of atherosclerotic plaques in images is an important task to determine their pathophysiology. Visual analysis is still as the most basic and often approach to determine the morphology of atherosclerotic plaques. In addition, computeraided methods have also been developed for identi cation of...

BACKGROUND Isolated atherosclerotic middle cerebral artery (MCA) disease is often difficult to differentiate from cardioembolic disease if intracranial atherosclerosis coexists with cardiac disease. OBJECTIVES To evaluate whether clinical and neuroradiological features of isolated MCA disease differ according to the underlying aetiology. METHODS Isolated MCA disease was defined as a unilate...

BACKGROUND There are few studies for evaluating wall characteristics of intracranial vertebral artery hypoplasia (VAH). The aim of this study was to determine wall characteristics of VAH with three-dimensional volumetric isotropic turbo spin echo acquisition (3D VISTA) images and differentiate between acquired atherosclerotic stenosis and VAH. METHODS Thirty patients with suspicious VAH by lu...