A novel and convenient protocol for the formation of amides via palladium-catalyzed N-dealkylative carbonylation of alkyl tertiary amines has been developed. In the presence of PdCl2(PhCN)2, CuO, PhCN and CO, a range of substituents on both aryl iodides and alkyl tertiary amines were compatible with the reaction to afford a series of N,N-disubstituted amides in moderate to excellent yields.

A heterogeneous, inexpensive, and environmentally friendly graphene oxide catalytic system for the C-H bond arylation of benzene enables the formation of biaryl compounds in the presence of aryl iodides. The oxygen functional groups in these graphene oxide sheets and the addition of KOtBu are essential for the observed catalytic activity. Reactions with various model compounds and DFT calculati...

The short interval between successive outbursts of RS Oph strongly suggests that it has a high mass white dwarf accreting at a high rate. This, in turn, suggests the possibility of prominent X-ray emission from RS Oph in quiescence. However, archival quiescent X-ray observations of RS Oph show it to be a modest soft X-ray source but not a strong 2–10 keV X-ray source. In this aspect, RS Oph dif...

A directed search for previously-undiscovered nova eruptions was conducted in the astronomical plate archives at Harvard College Observatory and Sonneberg Observatory. We found that an eruption of V2487 Oph (Nova Oph 1998) occurred on 1900 June 20. V2487 Oph was previously classified as a classical nova, which we identified as a probable recurrent nova based on its large expansion velocities an...

Monoalkyland dialkyl-imidazolium surfactants were used to prepare organically modified montmorillonites with markedly improved thermal stability in comparison with their alkyl-ammonium equivalents (the decomposition temperatures increased by ca. 100 °C). Such an increase in the thermal stability affords the opportunity to form syndiotactic polystyrene (s-PS)/imidazolium-montmorillonite nanocomp...

Cu(II)-catalyzed direct thiolation of azoles with thiols is described via intermolecular C-S bond formation/C-H functionalization under oxidative conditions. Both aryl thiols and aliphatic thiols are used as coupling partners, and furnished the thiolation products in moderate to good yields. The reaction is compatible with a wide range of heterocycles including oxazole, thiazole, imidazole and ...

Prophylactic and therapeutic efficacy against organophosphorus (OP) intoxication by pralidoxime (2-PAM) and atropine were studied and compared with sterically stabilized long-circulating liposomes encapsulating recombinant organophosphorus hydrolase (OPH), either alone or in various specific combinations, in paraoxon poisoning. Prophylactic and therapeutic properties of atropine and 2-PAM are d...

A bifunctional fusion protein consisting of organophosphorus hydrolase (OPH) and elastin-like polypeptide (ELP) was synthesized for the detoxification of organophosphorus compounds. ELPs undergo a reversible phase transition upon an increase in temperature, forming hydrophobic aggregates. This thermally triggered property of phase transition allows for a simple and rapid means of purifying the ...

We report a biosensor based on organophosphorus hydrolase (OPH) multilayer modified microcantilever (MCL) for detection of organophosphorus compounds (OPs). The assay is based on substrate-dependent bending of the OPH functionalized MCLs. The cantilever bending amplitude at equilibrium was a function of the concentration of paraoxon with the dynamic range extending from 10(-7) to 10(-3)M. The l...

Aryl bromides and iodides in the presence of catalytic amounts of a palladacycle derived from acetophenone oxime and 2 equivalents of potassium acetate react with ethylene under ambient pressure (15-30 psi) to give the corresponding vinylarenes. The reactions work with both electron-deficient and electron-rich aryl compounds and tolerate wide variety of common functional groups. Vinyl bromides ...