A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Artemether and Lumefantrine in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: buffer (0.1% v/v ortho phosphoric acid, PH – 3) in the ratio of 60:40 v/v delivered at a flow rate of 1.5 ml / min and wavelength of detection at ...

Artemether-lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria. It offers the advantage of rapid clearance of parasites by artemether and the slower elimination of residual parasites by lumefantrine. The combinatio...

In contrast, the treatment of severe/complicated childhood malaria appears to be evolving. The 2005 IAP Guideline followed the National Malaria Programme and recommended quinine, suggesting artesunate/artemether as less preferred alternatives(3). In 2008, it was modified as quinine with tetracycline/doxycycline/clindamycin(4) in line with the WHO 2006 statement. The National Guideline 2009(2) s...

Antimalarial drug resistance is a major obstacle to malaria control and eventual elimination. The routine surveillance for molecular marker of resistance is an efficient way to assess drug efficacy, which remains feasible in areas where malaria control interventions have succeeded in substantially reducing malaria transmission. Community based asexual parasite prevalence surveys were conducted ...

1076 Amid the dire statistics showing a deadly resurgence of malaria, a notable success has been scored in South Africa. In KwaZulu–Natal province, malaria cases increased from about 600 in 1991–1992 to more than 30,000 by 1999–2000 [1]. Then, after household spraying with DDT was implemented, and the new antimalarial combination artemether-lumefantrine (AL) was widely deployed (Figure 1), case...

BACKGROUND As Ethiopia is one of the sub-Saharan countries with a great burden of malaria the effectiveness of first line anti-malarial drugs is the major concern. The aim of this study was to synthesize the available evidence on the efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia. This was done by performing a meta-analysis of rec...

BACKGROUND Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on efficacy and safety in Africa were scarce. We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falci...

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 12, No. 11, November 2006 1799 6.4 nmol/L and that showed an H243Y mutant type codon. The role of such a polymorphism appears unclear. We found no association between the 3-bp indel in G7 and in vitro dhART susceptibility because mutants were regularly distributed in highly susceptible isolates and in isolates having a diminished susceptibil...

Background: Schistosomiasis is a chronic debilitating parasitic disease. Long-term repeated use of praziquantel (PZQ) for control of the disease morbidity may lead to resistance or reduced susceptibility to the drug. Artemether (ART), the anti-malarial drug may become an alternative therapy to PZQ as it also displays anti-schistosomal properties. Objective: To assess the effects of artemether e...