نتایج جستجو برای: apoptosis inducing factor

تعداد نتایج: 1012999  

Journal: :Neoplasia 2010
Songqing Fan Yikun Li Ping Yue Fadlo R Khuri Shi-Yong Sun

The small molecule 4EGI-1 was identified as an inhibitor of cap-dependent translation initiation owing to its disruption of the eIF4E/eIF4G association through binding to eIF4E. 4EGI-1 exhibits growth-inhibitory and apoptosis-inducing activity in cancer cells; thus, we were interested in its therapeutic efficacy in human lung cancer cells. 4EGI-1, as a single agent, inhibited the growth and ind...

2012
Giulio Preta Bengt Fadeel

Phosphatidylserine (PS) exposure on the cell surface has been considered a characteristic feature of apoptosis and serves as a molecular cue for engulfment of dying cells by phagocytes. However, the mechanism of PS exposure is still not fully elucidated. Here we show that the cytosolic release from mitochondria of apoptosis-inducing factor (AIF) is required for PS exposure during death receptor...

Journal: :journal of paramedical sciences 0
shaghayegh amirijavid biology department, science and research branch, islamic azad university, tehran mehrdad hashemi department of genetics, tehran medical branch, islamic azad university, tehran azim akbarzadeh pilot of biotechnology, pasteur institute of iran, tehran kazem parivar biology department, science and research branch, islamic azad university, tehran mansoor khakpoor biology department, islamic azad university, tabriz branch, tabriz

tumor necrosis factor- α (tnf-α) plays an important role in diverse cellular events such as septic shock, induction of other cytokines, cell proliferation and apoptosis. tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is currently attracting great interest as a potential anticancer drug. trail could selectively induce apoptosis in tumor cells in vitro and in vivo by a deat...

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