Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an α-helical structure from Lys(3) to Lys(21) and from Ala(25) to Val(35), linked by a hinge region. In this study, we demonstrated that both peptides showed high antimicrobial activities against multi-drug re...

ABSTRACT Background Antibiotic resistance makes antimicrobial peptides (AMPs) agents an alternative for treatment of pathogenic diseases. They are isolated from various animals invertebrates, vertebrates and plants. The present study shows the electrophoretic pattern of protein and peptides from Vicia Faba seed and reports our first attempt to study the antibacterial activity of Vicia faba...

Cancer is a multifaceted health issue that affects people globally and it considered one of the leading causes death with high percentage victims worldwide. In recent years, research studies have uncovered great advances in cancer diagnosis treatment. But, there are still major drawbacks conventional therapies used including severe side effects, toxicity, drug resistance. That why critical to d...

The pace of resistance against antibiotics almost exceeds that of the development of new drugs. As many bacteria have become resistant to conventional antibiotics, new drugs or drug resources are badly needed to combat antibiotic-resistant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobial peptides, rich sources existing in nature, are able to effectively kill mul...

Antibiotic resistance is an increasing public health concern around the world. Rapid increase in the emergence of multidrug-resistant bacteria has been the target of extensive research efforts to develop a novel class of antibiotics. Antimicrobial peptides (AMPs) are small cationic amphiphilic peptides, which play an important role in the defense against bacterial infections through disruption ...

The two-component regulatory system PhoP-PhoQ of Pseudomonas aeruginosa regulates resistance to cationic antimicrobial peptides, polymyxin B and aminoglycosides in response to low Mg2+ conditions. We have identified a second two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides. This system responds to limiting Mg2+, and is affe...

The ever-increasing number of drug-resistant bacteria is a major challenge in healthcare and creates an urgent need for novel compounds for treatment. Host defense antimicrobial peptides have high potential to become the new generation of antibiotic compounds. Antimicrobial peptides constitute a major part of the innate defense system in all life forms. Most of these cationic amphipathic peptid...

As antibiotic resistance increases worldwide, there is an increasing pressure to develop novel classes of antimicrobial compounds to fight infectious disease. Peptide therapeutics represent a novel class of therapeutic agents. Some, such as cationic antimicrobial peptides and peptidoglycan recognition proteins, have been identified from studies of innate immune effector mechanisms, while others...

An increasing number of reported cases of drug resistant Staphylococcus aureus and Pseudomonas aeruginosa, demonstrate the urgent need for new therapeutics that are effective against such and other multi-drug resistant bacteria. Antimicrobial peptides have for two decades now been looked upon as interesting leads for development of new therapeutics combating these drug resistant microbes. High-...

The emergence of drug-resistant pathogenic microbial strains has created an urgent need for new anti-infective molecule development. In order to avoid the spread of bacterial resistance, there is pressing demand to design a novel class of antibiotics having different mechanism of action in comparison to existing drugs. Natural antimicrobial peptides (AMPs) represent a novel class of molecules w...