The effect of an intensive aluminum-magnesium hydroxide antacid regimen (Maalox TC) on the disposition of intravenous enoxacin was studied in six male and six female volunteers. A single 400-mg dose of enoxacin was administered intravenously over 30 min on two occasions separated by a 1-week washout period. Thirty milliliters of Maalox TC was administered at -8, -2.5, -0.5, 1.5, 3.5, 5.5, 7.5, ...

STUDY OBJECTIVE The aim was to examine whether a high intake of aluminium containing antacids is a risk for Alzheimer's disease. DESIGN The mortality from dementia (1970-87), coded from death certificates as underlying or contributory cause of death, was compared with national rates in a cohort of patients who had surgery for gastroduodenal ulcer disease between 1911 and 1978. SETTING Patie...

3 McCallum RW, Kline MM, Curry N, Sturdevant RAL. Comparative efforts of metoclopramide and bethanechol on lower esophageal sphincter pressure in reflux patients. Gastroenterology 1975;68:1 114-8. McCallum RW, Berkowitz DM. The frequency of delayed gastric emptying in patients with gastroesophageal reflux and its response to metoclopramide and bethanechol. Gastroenterology 1978 ;74:1135. Gugler...

Methods During general anaesthesia exposure to a number of different agents is common. In addition, anti-inflammatory drugs, antiemetics, antacids, antibiotics and analgesics may be used, and all may elicit reactions. Follow up is recommended to include serum tryptase, specific IgE, skin prick test (SPT), intradermal tests (IDT), basophil activation test (BAT) and provocations. We present a cas...

Setting and participants. 664 patients aged ≥ 18 years who presented to their primary care provider in the Netherlands for new-onset dyspepsia between 2003 and 2006. Patients were assigned to either step-up or step-down therapy. Step-up therapy started with antacids, switched to H2-receptor antagonists, and then ended with proton pump inhibitors (PPIs). Step-down therapy employed the same medic...