Estrogens and androgens play a key role in regulating bone mass. However, their clinical use as bone anabolic agents is limited due to unwanted side effects, particularly in reproductive organs. In 2002, the synthetic ligand estren was described to reproduce the bone anabolic, nongenotropic effects of sex steroids while having no effect on the uterus or seminal vesicles. But in the current issu...

Osteoporosis is a major public health problem despite widespread use of bisphosphonate therapy. PTH(1-34) is a more effective treatment; but its use has been limited by side effects (hypercalcemia, tumor risk) and inconvenient dosing (daily injection). Long-acting forms of PTH are also effective but cause severe hypercalcemia, presumably from effects in kidney. We hypothesized that targeted del...

Of the three main components of the adult animal, bone, skeletal muscle and fat, the fat depots have the most variable growth rate. Growth of adipose tissue depends on the coordinated increase in cell size (hypertrophy) and cell number (hyperplasia) in the fat tissues. The endocrine system will affect the balance between anabolic and catabolic processes within the adipocyte and will influence t...

Anabolic drugs have recently widened therapeutic options in osteoporosis treatment, as they influence processes associated with bone formation to a greater extent and earlier than bone reabsortion. They positively affect a number of skeletal properties besides bone density, as intermittent administration of parathyroid hormone (PTH) results in an increase in the number and activity of osteoblas...

introduction: today sport is one of the important social criterion and athletes are trying to be a champion. therefore, there is an increase in misuse of doping agents especially anabolic-androgenic steroid. this study was carried out to determine the prevalence of the doping agents' abuse among male bodybuilders' and to access their knowledge about their side effects in kermanshah gymnasiums i...

BACKGROUND Several reports have implied progressive increase of performance-enhancing drug (PED) use among Iranian athletes. More importantly, most of the previous research in the Iranian population had mainly focused on the anabolic steroid abuse, and ignored other agents. OBJECTIVES The aim of this study was to investigate the prevalence and characteristics of PED use among bodybuilding ath...

A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives.

background: the most common drug abuse among athletes is anabolic steroids which lead to the development of cardiovascular diseases and sudden death. thus, the aim of this study was to evaluate cardiovascular outcomes of anabolic consumption in body building athletes. materials and methods: totally, 267 male athletes at the range of 20-45 years old with the regular consumption of anabolic stero...

The objective of this experiment was to determine the dose response of dexamethasone (DEX) on C2C12 myogenic cells and to examine the effects of the anabolic compounds estradiol (E), testosterone (T), and dihydrotestosterone (D) alone and in combination with DEX on proliferation and protein turnover in cultured C2C12 myogenic cells. In the first study, cells were treated with seven concentratio...