The present study is designed to search for the serum cytokine biomarker for liver injury induced by Dioscorea bulbifera L., which is a traditionally used herbal medicine in China. Mice were orally given various doses of ethyl acetate extract (EF) isolated from D. bulbifera for 12 days. The activity of serum alanine/aspartate transaminases (ALT/AST) was increased in EF (400 mg/kg)-treated mice....

Xenobiotic Triclosan (TCS) is of great concern because its existence in a variety personal, household and healthcare products continuous discharge water worldwide. Excessive use TCS-containing sanitizers antiseptic during the COVID-19 pandemic further increased content aquatic ecosystems. The present study deals with cyto-genotoxic effects biochemical alterations hatchlings Labeo rohita on expo...

During 1969, discussions between the Standards Subcommittee of the Laboratory Equipment and Methods Advisory Group of the Department of Health and Social Security and representatives of professional societies concerned with the assay of enzymes for diagnostic purposes led to the establishment of a working party to consider the current state of accuracy and reliability of diagnostic enzymology a...

The effects of 1,8-cineole on D-galactosamine/lipopolysaccharide (GalN/LPS)-induced shock model of liver injury was investigated in mice. The co-administration of GalN (700 mg kg(-1), i.p.) and LPS (5 microg kg(-1), i.p.) greatly elevated serum concentrations of tumour necrosis factor-alpha (TNF-alpha), alanine aminotransferase and aspartate aminotransferase, and induced massive hepatic necrosi...

Autoimmune Hepatitis (AIH) is a chronic liver disease where presentation of a self-antigen peptide by professional antigen presenting cells initiates liver damage and drives the differentiation of uncommitted CD4 helper T cells to a Th1 and Th17 response. However, the details of the pathogenic mechanisms remain unclear and current treatments stay non-specific, making the need for reliable anima...

The antitumor activity of Decalepis hamiltonii root extract (DHA) was investigated in Ehrlich Ascites Tumor (EAT) cell model in mice and the effect was compared with that of the anticancer drug, cyclophosphamide (CP). Treatment of EAT cell bearing mice with aqueous extract of Decalepis hamiltonii (50 mg/kg and 100 mg/kg b.w.) showed a significant reduction in ascites tumor volume, tumor cell co...

Building blocks with amine functionality are crucial in the chemical industry. Biocatalytic syntheses and chemicals derived from renewable resources increasingly desired to achieve sustainable production of these amines. As a result, materials such as furfurals, especially furfurylamines like 5-(hydroxymethyl)furfurylamine (HMFA) 2,5-di(aminomethyl)furan (DAF), gaining increasing attention. In ...

Introduction: Nowadays, a significant number of children with acute leukemia can be cured. Iron overload, related to blood transfusions and its long-term complications, remains problem. Elevated ferritin concentration is often observed in this group. The aim study was evaluate the prognostic value serum on outcomes treated for leukemia. Material: We studied 71 patients lymphoblastic (ALL) or my...

Due to its high incidence and poor prognosis, gastric cancer is an important health problem worldwide. The liver is the most frequent site of metastases. Advanced cancer in the setting of liver dysfunction poses a dilemma for physicians, as many cancer chemotherapeutic agents undergo hepatic metabolism. This paper reports the case of a patient with liver failure due to liver metastases of gastr...

background: celiac disease (cd) is an immune mediated condition that leads to small bowel atrophy that resolves with a gluten free diet (gfd). extra-intestinal manifestations of cd include hypertransaminasemia. in this study, the effects of a gfd on hypertransaminasemia in patients with newly diagnosed cd were studied. methods: ninety eight new diagnosed consecutive patients with cd 40 males an...