BACKGROUND The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuation at the start of inhalation. However, these recommendations were based on cl...

We devised an aerosol based demethylation therapy to achieve therapeutic efficacy in premalignant or in situ lesions of lung cancer, without systemic toxicity. Optimum regimens of aerosolized azacytidine (Aza) were designed and used in orthotopic human non-small cell lung cancer xenograft models. The therapeutic efficacy and toxicity of aerosol Aza were compared with intravenously administered ...

provides an overview of those studies as a basis for the consideration of aerosol deposition in the reduced gravity of Mars. Overall deposition: We first performed total deposition studies of 0.5-3 μm-diameter particles in normal gravity (1G), microgravity (μG) and hypergravity (~1.6G) using the NASA Microgravity Research Aircraft [2]. Subjects continuously breathed aerosol from a reservoir at ...

Effective management of asthma is dependent on achieving adequate delivery of the drugs into the lung. Inhalers come in the form of dry powder inhalers (DPIs) and metered dose inhalers (pMDIs) with the former requiring a deep fast breath for activation while there are no restrictions on inhalation rates for the latter. This study investigates two aerosol medication delivery methods (i) an ideal...

Detailed regional deposition of inhaled particles was investigated in young adults (n = 11) by use of a serial bolus aerosol delivery technique. A small bolus (45 ml half-width) of monodisperse aerosols [1-, 3-, and 5-microns particle diameter (Dp)] was delivered sequentially to a specific volumetric depth of the lung (100-500 ml in 50-ml increments), while the subject inhaled clean air via a l...

This letter describes the first application of the in a 3-D chemical transformation and transport model. The QMOM simultaneously tracks an arbitrary (even) number of moments of a particle size distribution directly in space and time without the need for explicitly representing the distribution itself. The host 3-D model, the Global Chemistry Model driven by Observation-derived meteorological da...

The therapeutic administration of medical aerosols has been a standard adjunct to treatment of critically ill patients since positive-pressure mechanical ventilators were introduced over 60 years ago, and most ventilators can operate a jet nebulizer in synchrony with mechanically delivered breaths. However, for the first 40 years, little was known about the efficiency of aerosol delivery during...

A new method of synthesising nanoparticle-functionalised nanostructured materials via Aerosol Assisted Chemical Vapour Deposition (AACVD) has been developed. Co-deposition of Au nanoparticles with WO(3) nanoneedles has been used to deposit a sensing layer directly onto gas sensor substrates providing devices with a six-fold increase in response to low concentrations of a test analyte (ethanol).

Whereas many ecosystem characteristics and processes influence mercury accumulation in higher trophic-level organisms, the mercury flux from the atmosphere to a lake and its watershed is a likely factor in potential risk to biota. Atmospheric deposition clearly affects mercury accumulation in soils and lake sediments. Thus, knowledge of spatial patterns in atmospheric deposition may provide inf...

The deposition mode ice nucleation efficiency of various dust aerosols was investigated at cirrus cloud temperatures between 196 and 223 K using the aerosol and cloud chamber facility AIDA (Aerosol Interaction and Dynamics in the Atmosphere). Arizona test dust (ATD) as a reference material and two dust samples from the Takla Makan desert in Asia (AD1) and the Sahara (SD2) were used for the expe...