نتایج جستجو برای: adenoviral vector

تعداد نتایج: 201214  

Journal: :Molecular cancer therapeutics 2002
Mack N Barnes Candace J Coolidge Akseli Hemminki Ronald D Alvarez David T Curiel

The purpose of this review article is to present a logical rationale for the investigation of conditionally replicative adenoviral vectors for the treatment of ovarian carcinoma. A medline database search was performed to identify relevant articles in the English language for the years 1966 to present. The key words used included replicative adenovirus, conditionally replicative adenovirus, tra...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2001
S Wen R M Driscoll D B Schneider D A Dichek

Adenoviral vectors are promising agents for vascular gene transfer. Their use, however, is limited by inflammatory host responses, neointima formation, and brevity of transgene expression. Inclusion of the immunomodulatory adenoviral E3 genes in a vector might prevent inflammation and neointima formation and prolong transgene expression. We compared 2 adenoviral vectors in a model of in vivo ge...

Journal: :International Journal of Medical Sciences 2006
Hongwei Li Jin Zhong Li Debra D. Pittman Andy Amalfitano Gerald R. Hankins Gregory A. Helm

Osteogenic potentials of some recombinant human bone morphogenetic protein (BMP) first-generation adenoviral vectors (ADhBMPs) are significantly limited in immunocompetent animals. It is unclear what role expression of viral proteins and foreign proteins transduced by adenoviral vectors play in the host immune response and in ectopic bone formation. In this study two sets of experiments were de...

Journal: :Human gene therapy 1999
H Mizuguchi M A Kay

We previously developed a two-plasmid in vitro ligation method that did not require a recombination step to produce new recombinant E1- or E1/E3-deleted adenoviral vectors. In this study, we have modified the system to improve the simplicity of vector construction and, in addition, to allow for production of an E1/E4-deleted vector.

Journal: :Gynecologic oncology 2005
Katsuyuki Hamada Morito Sakaue Asis Sarkar Stepanie Buchl William Satterfield Michale Keeling Jagannandha Sastry Jack A Roth Michele Follen

BACKGROUND One major concern about adenoviral vectors for repetitive gene delivery is the induction of an immune response to the vector, thus impeding effective gene transduction. METHODS To assess the immune response to the adenoviral vector, repetitive gene dosing was performed into rhesus monkey cervix and C3H mouse skin using the adenoviral vector carrying the lacZ gene. Three repetitive ...

Ali Ramazani, Alireza Biglari, Javad Tavkoli Bazzaz Maryam Foroutan Jazi Mehdi Eskandari Paul Kingston Saeideh Mazloomzadeh

Objective(s):Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (TGF-β). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGFβ1 modulator. In this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromod...

Journal: :Journal of virology 2003
Anja Ehrhardt Hui Xu Mark A Kay

Previously we showed that recombinant adenoviral helper-dependent (HD) vectors result in long-term transgene expression levels in vivo which slowly declined by 95% over a period of 1 year. In this study, we further establish that this was not predominantly immune mediated. To determine if cell turnover was responsible for the loss of transgene expression, we induced rapid hepatocyte cell cyclin...

Journal: :Blood 2001
A M Gallo-Penn P S Shirley J L Andrews S Tinlin S Webster C Cameron C Hough C Notley D Lillicrap M Kaleko S Connelly

Canine hemophilia A closely mimics the human disease and has been used previously in the development of factor VIII (FVIII) protein replacement products. FVIII-deficient dogs were studied to evaluate an in vivo gene therapy approach using an E1/E2a/E3-deficient adenoviral vector encoding canine FVIII. Results demonstrated a high level of expression of the canine protein and complete phenotypic ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2000
S Wen D B Schneider R M Driscoll G Vassalli A B Sassani D A Dichek

The utility of adenoviral vectors for arterial gene transfer is limited by the brevity of their expression and by inflammatory host responses. As a step toward circumventing these difficulties, we used a rabbit model of in vivo arterial gene transfer to test 3 second-generation vectors: a vector containing a temperature-sensitive mutation in the E2A region, a vector deleted of E2A, and a vector...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
N Morral W O'Neal K Rice M Leland J Kaplan P A Piedra H Zhou R J Parks R Velji E Aguilar-Córdova S Wadsworth F L Graham S Kochanek K D Carey A L Beaudet

The efficiency of first-generation adenoviral vectors as gene delivery tools is often limited by the short duration of transgene expression, which can be related to immune responses and to toxic effects of viral proteins. In addition, readministration is usually ineffective unless the animals are immunocompromised or a different adenovirus serotype is used. Recently, adenoviral vectors devoid o...

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