Previous work showed that acute myelocytic leukemia blasts accumulate less long chain polyglutamates of methotrexate (MTX) than acute lymphocytic leukemia blasts when incubated with this radiolabeled antifolate. This difference likely explains the increased sensitivity of lymphoid leukemias to short-term exposure of MTX as compared with myeloid leukemias. In this study, we examined the basis fo...

By ROBERT S. MENDELSOIIN, DONALD M. WATKIN, ANN P. HORBETr AND J OHN L. FAHEY R ECENT STUDIES have demonstrated that virtually all the vitamin B12 in normal serum is bound to serum proteins.1 In chronic myelocytic leukemia tile serum B12 concentration may be increased from 2 to 30 times normal levels.24 At these increased levels, all or almost all of the B12 is protein-bound. However, normal se...

Daunorubicin induces complete remissions during the first 5 days (25#{176}/o) or due to in about 500/0 of patients with acute prosepsis during the second and third week myelocytic leukemia. The median duration (25#{176}/o). Long-term survivals are more freof these remission is 26 mo. Failures are quent than in the other acute granulocytic mainly due to hemorrhages as a result of leukemias. diss...

Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional Chinese medicine herbal formulas used for therapy chronic myelocytic leukemia in China hundreds years. Although monomeric indirubin has been treatment human leukemia. However, due to low water solubility, poor pharmacokinetic properties therapeutic effects are major obstacle, had significantly limited its clini...

In a previous epidemiological study on acute myelocytic leukemia (M. M. Crane et al., Cancer Epidemiol. Biomark. Prev., 5: 639-644, 1996), clonal aberrations in chromosome 8 have been reported to be in excess in smokers and in workers exposed to paints. In that study, cytogenetics was performed after therapy. In our report, we describe a population-based survey on nonlymphocytic leukemias in no...

By using an indirect immunofluorescence technique, the distribution of poly(ADP-ribose) synthesis in human blood cells was investigated. The antibody used was reactive with poly(ADP-ribose) larger than trimers. The specific immunofluorescence of poly(ADP-ribose) synthesized in situ from NAD+ was observed in nuclei of lymphocytes and monocytes in normal peripheral blood. No immunofluorescence, h...