Microbicides are compounds that applied vaginally or rectally, protect the user from sexually transmitted infections. Although no commercial product is yet available, many candidates are under development. A leading candidate, VivaGel (SPL7013 Gel) is the product of nanotechnology. The active ingredient is SPL7013, a dendrimer that was designed specifically with HIV and HSV antiviral activity a...

BACKGROUND In retrospective studies of the health effects of home and garden pesticides, self-reported information typically forms the basis for exposure assessment. Study participants generally find it easier to remember the types of pests treated than the specific pesticides used. However, if the goal of the study is to assess disease risk from specific chemicals, the investigator must be abl...

Issue Assessment of the potential risks to health from natural health products containing synephrine and/or octopamine in combination with caffeine. various products not licensed for sale in Canada Type of Product Natural Health Products Common Name (if any) various Medicinal/Active Ingredient(s) Synephrine and/or Octopamine and Caffeine Dosage Form(s) various Strength(s) various Route of Admin...

Incomplete degradation of control products and subsequent carryover of active ingredient to the next year are operational concerns for control agencies. Altosid XR briquets were weighed before and after 6-18 months of exposure in temporary wetlands to determine the rate of physical degradation of the briquets. Degradation rate was influenced mainly by the number of days a briquet remained under...

BACKGROUND Allium sativum, the active ingredient in garlic, is known to have a beneficial effect on major cardiovascular risk factors, including dyslipidemia, blood pressure, blood glucose and insulin levels. However, the data on the significance of these effects are inconsistent due to methodological limitations, especially the use of whole garlic cloves which does not allow controlled dosing ...

In this study, tamarind (Tamarindus indica L.) seed extracts with potential antioxidant activity and toxicity to cancer cells were developed as functional foods and nutraceutical ingredients in the form of emulsion gel beads. Three extracts were obtained from ethanol and water: TSCH50, TSCH95 and TSCH. All extracts exhibited high potential for superoxide anion scavenging activity over the IC50 ...