The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes. The PC1/3 is a pivotal enzyme of this family that participates in the proteolytic maturation of prohormones and neuropeptides inside the regulated secretory pathway. In this paper we demonstrate that mouse proprotein convertase 1/3 (mPC1/3) has a ...

The cofactor function of human Factor VIII in Factor X activation was investigated by an initial-rate assay of 3H-Factor X activation in the presence of human factor IXa, Ca2+, and either phospholipid or fresh washed human platelets. Purified Factor VIII that has not been activated by thrombin or Factor Xa supports Factor X activation after a lag of several minutes. A specific inhibitor of Fact...

In this paper, we present an explicit solution to H∞ full-information control for discrete-time systems with multiple input delays. Our solution is given in terms of one standard Riccati difference equation of the same order as the plant under investigation. Thus, it has much computational advantage over methods such as system augmentation. As special cases, solutions to the H∞ control problem ...

Circadian rhythm has been linked to cancer genesis and development, but the detailed mechanism by which circadian disruption accelerates tumor growth remains unclear. The purpose of this study was to investigate the effect of circadian disruption on tumor growth and metastasis in male C57BL/6 mice, using an experimental chronic jet lag model. Lewi...

This paper discusses the stabilization of Takagi–Sugeno (T–S) fuzzy systems with bounded and time-varying input delay. The robust stabilization via state feedback is first addressed, and delay-dependent stabilization conditions are proposed in terms of LMIs. Observer-based feedback stabilization is also discussed for T–S fuzzy input delay systems without uncertainties. A separate design princip...

Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses toward environmental allergens and protecting against allergic diseases. Still, the precise molecular cues that underlie their transcriptional and functional specification remain elusive. Here, we show that the cytokine activin-A instructs the generation of CD4+ T cells that express the Tr1-cell-associated...

lag is a general term applied to coarse grained (> 2 mm), hard, but partially weathered rockfragments, which are concentrated at the surface through attrition of finer materials. based on morphology,mineralogy and the origin of lag from the cobar region of australia, lag may be conveniently grouped intothree broad morpho-mineralogical categories; (a) those with a rough, blocky, lithic morpholog...