Endocrine diseases are frequently accompanied by diabetes mellitus and treatment of an underlying endocrine disease often improves glucose control. The co-occurrence of acromegaly and Cushing's syndrome is extremely rare. We herein describe a patient who showed a dramatic improvement in glucose control following treatment for co-existing acromegaly and Cushing's syndrome. An adrenal mass was in...

Visit our website at: http://pituitary.mgh.harvard.edu Patients with acromegaly are known to have reduced life expectancy. Prior to effective treatment for acromegaly, more than 80% of acromegalic patients died of cardiovascular disease before age 60 (1,2). Even in the modern era with available therapy, mortality in active acromegaly is still increased about twoto three-fold and the major cause...

Acromegaly is a rare disease with an estimated incidence of 2.5 cases per million (cpm) per year according to Spanish national data. In 1997 the Spanish Acromegaly Registry (Registro Español de Acromegalia [REA]) was set up. The main objective of the project was to collect epidemiological, clinical and biochemical data, as well as data on treatments and outcomes of acromegaly in Spain. Data ent...

Sixteen acromegalic patients underwent echocardiography, phonocardiography, stress electrocardiography with Thallium perfusion scanning and gated radioisotope left ventricular angiocardiograms. Abnormalities consisting of increased echo left ventricular mass index, low velocity of circumferential fiber shortening or elevated pre-ejection period to left ventricular ejection time ratio were found...

The ideal -method for the treatment of acromegaly remains uncertain. Evidence of local pressure from a pituitary tumour offers an absolute indication for treatment, and this has usually been surgical decompression ; however, when treatment has been given by external deep x-ray therapy the majority of such patients have shown improvement in their visual-field defects (Fraser and Joplin, 1961). W...

Acromegaly is debilitating disease occasionally refractory to surgical and medical treatment. Stereotactic radiosurgery, and in particular Gamma Knife surgery (GKS), has proven to be an effective noninvasive adjunct to traditional treatments, leading to disease remission in a substantial proportion of patients. Such remission holds the promise of eliminating the need for expensive medications, ...

INTRODUCTION Acromegaly is a rare disorder characterized by excess secretion of growth hormone and its principle mediator, insulin-like growth factor-1. Although acromegaly is frequently associated with osteoarthritis, the outcome of arthroplasty in this population is not documented. CASE REPORT We report here a case of aseptic loosening of an uncemented total hip arthroplasty acetabulum in a...

Endoscopic endonasal transsphenoidal surgery (EETS) is a widely accepted technique for the surgical resection of pituitary tumours. In this report, we present our single-centre experience with EETS adenomas, mainly focusing on its efficacy and postoperative complications. Among 100 patients who underwent EETS, 57 (57%) were female 43 (43%) male. The mean age was 51.55 ± 13.51 years. Nonfunction...

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac abnormalities. However, the long-term cardiac effects of treatment for acromegaly have not been studied in patients who have already developed chronic congestive heart failure (CHF). We reviewe...

OBJECTIVE To establish a baseline pattern of care across academic and community settings, it is important to examine the contemporary treatment of acromegaly. We characterized medical treatment patterns for acromegaly in the US to develop a basis for tracking concordance with guidelines. RESEARCH DESIGN AND METHODS Acromegaly patients were identified in two commercial claims databases for thi...