The design, synthesis and pharmacology of novel long-acting exenatide analogs for the treatment of metabolic diseases are described. These molecules display enhanced pharmacokinetic profile and potent glucoregulatory and weight lowering actions compared to native exenatide. [Leu(14)]exenatide-ABD is an 88 residue peptide amide incorporating an Albumin Binding Domain (ABD) scaffold. [Leu(14)]exe...

BACKGROUND Shoulder pain is a common problem, with 30% to 50% of the American population affected annually. While the majority of these shoulder problems improve, there is a high rate of recurrence, as 54% of patients experience persistent symptoms 3 years after onset. PURPOSE Posterior shoulder tightness has been shown to alter glenohumeral (GH) kinematics. Clinically, posterior shoulder con...

We present in this paper a simple and e cient synchronizer algorithm for Asynchronous Bounded Delay Networks. In these networks each processor has a local clock, and the message delay is bounded by a known constant. The algorithm improves on an earlier synchronizer for this network model, presented by Chou et al.[CCGZ90]. Moreover, using a mathematical model for this type of synchronizer, we sh...

Many commonly used numerical methods for the solution of Boundary Value Problems (BVPs) for Ordinary Di erential Equations (ODEs) contain signi cant components that can be parallelized easily, and recent investigations have shown that substantial speedups are attainable on machines with a modest number of processors. However, a stage in most of these methods is the numerical solution of an Almo...

The commonly used asynchronous bounded delay (ABD) network models assume a fixed bound on message delay. We propose a probabilistic network model, called asynchronous bounded expected delay (ABE) model. Instead of a strict bound, the ABE model requires only a bound on the expected message delay. While the conditions of ABD networks restrict the set of possible executions, in ABE networks all as...

Ionotropic glutamate receptor (iGluR) subunits contain a large N-terminal domain (NTD) that precedes the agonist-binding domain (ABD) and participates in subunit oligomerization. In NMDA receptors (NMDARs), the NTDs of NR2A and NR2B subunits also form binding sites for the endogenous inhibitor Zn(2+) ion. Although these allosteric sites have been characterized in detail, the molecular mechanism...

We propose a crash safe and pseudo-stabilizing algorithm for implementing an atomic memory abstraction in a message passing system. Our algorithm is particularly appealing for multi-core architectures where both processors and memory contents (including stale messages in transit) are prone to errors and faults. Our algorithm extends the classical fault-tolerant implementation of atomic memory t...

The homeotic Abdominal-B (Abd-B) gene expression depends on a modular cis-regulatory region divided into discrete functional domains (iab) that control the expression of the gene in a particular segment of the fly. These domains contain regulatory elements implicated in both initiation and maintenance of homeotic gene expression and elements that separate the different domains. In this paper we...