Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, quinolines. Thus, through the Passerini Ugi multicomponent (P-3CR U-4CR), we obtained thirteen in moderate high yield following established protocol fundamentally varying electron-rich carboxylic acid reactants. UV/Vis spectr...