نتایج جستجو برای: 450 inhibition

تعداد نتایج: 351106  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعتی شاهرود 1389

بازهای شیف نقش کلیدی در توسعه شیمی کئوردیناسیون دارند. یکی ازمهم ترین و بیشترین کاربردهای این ترکیبات این است که مانند پورفیرین ها فرآیند انتقال اکسیژن را با الگو برداری از آنزیم سیتوکروم 450p- به راحتی انجام داده و می توانند هیدروکربن های ساده را عامل دار کرده و واکنش های مختلف آنها راهدایت کنند. در چند سال گذشته تحقیقات وسیعی پیرامون نقش کاتالیزوری کمپلکس های بازشیف به منظور الگوبرداری از نقش...

2010
Agustin Liotta Gürsel Çalışkan Rizwan ul Haq Jan O. Hollnagel Uwe Heinemann Christoph J. Behrens

Partial disinhibition is required for transition of stimulus-induced sharp wave1 ripple complexes into recurrent epileptiform discharges 2 in rat hippocampal slices 3 Agustin Liotta#, Gürsel Çalışkan#, Rizwan ul Haq, Jan O. Hollnagel , Anton 4 Rösler, Uwe Heinemann 2 and Christoph J. Behrens 5 6 Institute of Neurophysiology, Institute for Physiology and 7 NeuroCure Research Center, Charité Univ...

2016
Naomi Hauser Tanmay Sahai Rocco Richards Todd Roberts

Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The drug is commonly used to prevent graft rejection in solid organ transplant and graft-versus-host disease in hematopoietic stem cell transplant patients. Tacrolimus has a narrow therapeutic index with variable oral bioavailability and metabolism via cy...

Journal: :Cancer research 1984
R A Prough M I Brown G A Dannan F P Guengerich

Seven isozymes of cytochrome P-450 were tested to establish whether they could N-oxidize azoprocarbazine to form the two isomeric azoxy metabolites after optimizing the reconstitution of various purified isozymes with regard to substrate concentration, exogenous lipid, and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reductase concentration. Two isozymes, cytochromes...

Journal: :The Journal of Experimental Medicine 1972
Alvito P. Alvares Susan Leigh Jonathan Cohn Attallah Kappas

The rat liver mixed function oxidase system which is responsible for the metabolism of endogenous and exogenous compounds has been shown to be affected by lead and methyl mercury. Administration of these environmental pollutants to rats results in a decrease in cytochrome P-450 content and inhibition of in vitro N-demethylase and hydroxylase activities. The in vitro enzyme-inhibiting effects of...

Journal: :Applied and environmental microbiology 1994
S Pospísil P Sedmera V Havlícek J Tax

Metyrapone, a potent cytochrome P-450 inhibitor, added at 9 mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-O-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear mag...

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