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The transcriptional activation of keratinocytes has essential roles for the specific types immune response skin. However, necessary and sufficient conditions in development psoriasis have never been identified. We previously demonstrated that mice lacking TRAF6 specifically are resistant to psoriatic inflammation induced by imiquimod. In addition, we found daily topical treatment with anisomyci...
IKK/NF-kB signalling controls inflammation and cell death is important to maintain tissue homeostasis. Keratinocyte-specific deletion of IKK2 (IKK2E-KO) leads TNFR1-dependent skin in mice. IKK2E-KO mice showed increased numbers apoptotic necrotic keratinocytes, upregulation inflammatory cytokines mediators the epidermis. We proposed that keratinocyte could trigger inflammation. Receptor Interac...
recensé : James R. Fichter (dir.), British and French Colonialism in Africa, Asia the Middle East: Connected Empires across Eighteenth to Twentieth Centuries, Cham, Palgrave Macmillan, 2019, 353 p.
Ebola virus (EBOV) and Marburg virus (MARV) belong to the family Filoviridae and cause severe hemorrhagic fever in humans and nonhuman primates. Despite the discovery of EBOV (Reston virus) in nonhuman primates and domestic pigs in the Philippines and the serological evidence for its infection of humans and fruit bats, information on the reservoirs and potential amplifying hosts for filoviruses...
We report the discovery of four high-redshift objects (3.3 < z < 4) observed behind the rich cluster CL0939+4713 (Abell 851). One object (DG 433) has a redshift of z = 3.3453; the other three objects have redshifts of z ≈ 4: A0 at z = 3.9819, DG 353 and P1/P2 at z = 3.9822. It is possible that all four objects are being lensed in some way by the cluster, DG 433 being weakly sheared, A0 being st...
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