OBJECTIVE To test the ability of a single injection of a sustained-release formulation of moxidectin (moxidectin SR) to protect dogs against heartworm infection for 180 days after inoculation with infective third-stage larvae (L3) of Dirofilaria immitis. ANIMALS 32 adult mixed-breed dogs. PROCEDURE Dogs were allocated to 4 groups on the basis of weight and sex. Dogs were injected SC with sa...

A laminin-derived synthetic peptide, Cys-Asp-Pro-Gly-Tyr-Ile-GlySer-Arg-NHz (CDPGYIGSR-NH2), containing an active site for cell binding inhibited both angiogenesis and solid tumor growth. It potently suppressed both embryonic angiogenesis of the chick chorioallantoic membrane and migration of vascular endothelial cells induced by a tumorconditioned medium but neither the in vitro proliferation ...

The antitumor activity of 2,3-dihydroxybutyraldehyde on Ehrlich carcinoma, Sarcoma 180, and Yoshida AH 130 hepatoma, as well as the aldehyde dehydrogenase activity in these tumors, was studied. 2,3-Dihydroxybutyraldehyde at nontoxic doses (500 mg/kg body weight i.p. daily for 7 days) slowed down the growth of solid and ascites tumors in mice. The treatment completely prevented the development o...

Deep vein thrombophlebitis (DVT) and pulmonary emboli (PE) have been uncommonly reported manifestations of systemic lupus erythematosus (SLE). This may be partly due to their being masked by other more familiar lesions of the lungs and extremities in SLE. We have identified 17 patients with SLE from a population of 180 being followed up prospectively who had 21 attacks of DVT and/or PE. Of the ...

Chest tube is a flexible plastic tube used to discharge secretion in the cavity between the lungs and chest named pleural cavity. Normally, there is a small amount of fluid in the cavity between the lungs and chest; This fluid helps the movement of lungs during breathing without abrasion. Entrance of bit of air, blood or pus because injury in the pleural cavity can prevent the lungs from fully ...