Osteoclast activity and the fine balance between bone formation and resorption is affected by inflammatory factors such as cytokines and T lymphocyte activity, mediated by major histocompatibility complex (MHC) molecules, in turn regulated by the MHC class II transactivator (MHC2TA). We investigated the effect of functional polymorphisms in the MHC2TA gene (CIITA), and two additional genes; C-t...

Seven isozymes of cytochrome P-450 were tested to establish whether they could W-oxidize azoprocarbazine to form the two isomerie azoxy metabolites after optimizing the reconstitution of various purified isozymes with regard to substrate concentration, exogenous lipid, and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reducÃ-aseconcentration. Two isozymes, cytochromes...

Pulmonary hypertension (PH) is a rare and progressive disease characterized by an inflammatory status and vessel wall remodeling, resulting in increased pulmonary artery resistance. During the last decade, treatments have been proposed; most of them target the endothelial pathways that stimulate smooth muscle cell relaxation. However, PH remains associated with significant morbidity. We hypothe...

The four most stable C(s) conformers of glycine have been investigated using a variety of quantum-mechanical methods based on Hartree-Fock theory, density-functional theory (B3LYP and statistical average of orbital potential), and electron propagation (OVGF) treatments. Information obtained from these models were analyzed in coordinate and momentum spaces using dual space analysis to provide in...

Introdução: A doação e o transplante de órgãos tecidos é um tema interesse multiprofissional pauta importante quanto à promoção políticas saúde pública referentes aplicação dessa terapêutica. Objetivos: Apresentar uma análise do cenário da para pós-morte na 16a Região Saúde estado Rio Grande Sul entre os anos 2010 2020, com enfoque avaliação das negativas familiares a doação. Métodos: Foi reali...