We used a sensitization approach that involves replacement of the gatekeeper residue in a protein kinase with one with a different side chain. The activity of the enzyme with a bulky gatekeeper residue, such as methionine, cannot be inhibited using bumped kinase inhibitors (BKIs). Here, we have used this approach to study Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1). The m...

Accident prevention is of great significance in avoiding or reducing all kinds casualties and economic losses, one the main challenges for social sustainable development. Hence, it has been an active research field many decades around world. To master status accident prevention, explore knowledge base hot trends, 1294 papers from WOS retrieval platform SCIE SSCI databases 1990 to 2021 were sele...

Entre los adultos mayores (AM) prevalecen enfermedades como la diabetes tipo 2 (DT2), por ello, desde psicología, se proponen intervenciones para mejorar su calidad de vida. A vez, las con soporte social han mostrado mejoras en variables psicológicas asociadas a DT2. De ahí que el propósito este estudio consistió identificar características (SS), AM Para realizó una búsqueda sistemática arrojó ...

Two hydrogen-related donors in anatase TiO 2 —interstitial hydrogen ( H i ) and substituting for oxygen O )—are addressed by means of ab initio density functional theory vibrational mode spectroscopy. First-principles calculations infrared (IR) absorption measurements reveal that forms an OH bond lying the basal plane crystal characterized a stretch local (LVM) with frequency 3412 cm − 1 . Acc...

Bu çalışmada, 2012 ve 2020 yıllarında benzer özellikteki hanelerden toplanan veriler ile Adana İli Hane Halkı Tüketim Davranışlarını yıllar itibariyle tüketim kalıplarındaki değişimi tespit etmek amaçlanmıştır. amaçla ilinde yaşayan tüketicilerin satın alma, alma sonrası alışkanlıkları, yeri tercihlerinde etkili faktörler, hizmet tüketimi eğilimleri, dayanıklı mallarına ilişkin sahiplik oranlar...