In the current paper, an HPLC/UV method was developed and validated for determination of wogonin in plasma. Considerable attention was paid to the preparation of standard samples and factors affecting drug distribution. A preparation procedure was devised to simulate the conditions the drug is expected to experience in vivo while pointing to the shortcomings of previously published methods. The...

The androgen receptor (AR) signaling pathway continues to be active in hormone resistant prostate cancer (HRPC) and can inappropriately activate transcription. Consequently the AR is a therapeutic target for HRPC. We reported that PC-SPES is active against HRPC, partly due to its actions in down-regulating AR protein expression and modulating cell cycle. Further investigation has identified fiv...

Tüm dünyada büyüyen bir sa?l?k sorunu olan kanser, kardiyovasküler hastal?klardan sonra ikinci en önemli ölüm nedenidir. Kanser tedavisinde kullan?lan klasik yöntemlerin (cerrahi, radyoterapi, kemoterapi vb.) tedavide istenilen düzeyde etkili olamamas? ara?t?rmac?lar? kanser yeni terapötiklerin ke?fine ve geli?tirilmesine yönlendirmi?tir. Flavonoidlerin alt grubu flavonlar?n biyokimyasal farmak...