The lymphatic system is part of the circulatory system and plays a key role in normal vascular function. Its failure plays a crucial role in the development and maintenance of various diseases including liver diseases. Lymphangiogenesis (the growth of lymphatic vessels) and changes in the properties of lymphatic vessels are associated with pathogenesis of tumor metastases, ascites formation, li...

The metabolic syndrome (MetS) consists of a constellation of vascular risk factors and metabolic abnormalities comprising (1) centrally distributed obesity; (2) atherogenic dyslipidemia, characterized mainly by elevated triglycerides and decreased high-density lipoproteins; (3) high blood pressure; and (4) hyperglycemia.1 This cluster of highly interrelated factors appears to increase the indiv...

METHODS The spleen has a complex and distinct vascular structure compared with the vessel of other organs. So the vascular lesions, which are the majority of nonlymphoid primary tumors of the spleen, can display a wide variety of histologic features in this organ. Sclerosing angiomatoid nodular transformation (SANT) is a recently recognized splenic vascular lesion (first described by Martel in ...

A patient with type 2 diabetes carries a cardiovascular risk similar to that of a non-diabetic with a prior history of myocardial infarction. Endothelial dysfunction, an early event in the pathogenesis of atherosclerosis is present in diabetes mellitus in the absence of clinical cardiovascular disease. The assessment of the endothelium dependent vasodilatory effect in response to various stimul...

The metabolic syndrome (MetS) consists of a constellation of vascular risk factors and metabolic abnormalities comprising (1) centrally distributed obesity; (2) atherogenic dyslipidemia, characterized mainly by elevated triglycerides and decreased high-density lipoproteins; (3) high blood pressure; and (4) hyperglycemia.1 This cluster of highly interrelated factors appears to increase the indiv...

background and objective: vascular endothelial growth factor (vegf) and its receptors (vegf-r1 and r2) are major regulators of angiogenesis. this study was designed to assess serum levels of vegf and vegf-r1 and their prognostic significance in newly diagnosed childhood acute leukemia. materials and methods: for this purpose, vegf and vegf-r1 were determined using enzyme linked immuno-sorbant a...

Systemic sclerosis (SSc, scleroderma) is a chronic, multisystem connective tissue disorder affecting the skin and various internal organs. Although the disease is characterized by a triad of widespread microangiopathy, fibrosis and autoimmunity, increasing evidence indicates that vascular damage is a primary event in the pathogenesis of SSc. The progressive vascular injury includes persistent e...

Background and Purpose: Microaneurysms and fibrinoid necrosis of cerebral cortical arteries have been reported to be related to the pathogenesis of intracerebral hemorrhage associated with cerebral amyloid angiopathy. To elucidate the pathogenesis of such vascular lesions, we conducted the present study. Methods: Five hundred serial sections from brain tissue of a patient with severe amyloid an...

TAFRO syndrome is defined by the presence of thrombocytopenia, hydrops, fever, fibrosis, renal dysfunction, and organomegaly can be seen with idiopathic multicentric Castleman disease (iMCD) or as an isolated process without iMCD. The pathophysiology not well understood, but it thought to related hypercytokinemia. Subclinical hypothyroidism may a potential factor in pathogenesis symptomatology ...

Vascular complications are extraintestinal manifestations of ulcerative colitis. Although there has been some controversy regarding the association between colitis and stroke, hypercoagulability systemic inflammation thought to be possible factors contributing stroke pathogenesis. Herein, we report a case recurrent ischemic with significant arterial stenosis. Cerebral vasculitis was suggested i...