نتایج جستجو برای: vaca c

تعداد نتایج: 1057856  

2012
Shu Sahara Mitsushige Sugimoto Ratha-Korn Vilaichone Varocha Mahachai Hiroaki Miyajima Takahisa Furuta Yoshio Yamaoka

BACKGROUND Infection with cagA-positive, cagA EPIYA motif ABD type, and vacA s1, m1, and i1 genotype strains of Helicobacter pylori is associated with an exacerbated inflammatory response and increased risk of gastroduodenal diseases. However, it is unclear whether the prevalence and virulence factor genotypes found in Southeast Asia are similar to those in Western countries. Here, we examined ...

Journal: :The Journal of Cell Biology 2007
Nils C. Gauthier Pascale Monzo Teresa Gonzalez Anne Doye Amanda Oldani Pierre Gounon Vittorio Ricci Mireille Cormont Patrice Boquet

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are endocytosed by a clathrin- independent pathway into vesicles named GPI-AP-enriched early endosomal compartments (GEECs). We recently showed that the vacuolating toxin VacA secreted by Helicobacter pylori is endocytosed into the GEECs (Gauthier, N.C., P. Monzo, V. Kaddai, A. Doye, V. Ricci, and P. Boquet. 2005. Mol. Biol. Cell. 16:4852...

Journal: :Gut 2000
L J van Doorn P M Schneeberger N Nouhan A P Plaisier W G Quint W A de Boer

BACKGROUND Virulence factors of Helicobacter pylori are associated with peptic ulcer disease and may be also associated with the efficacy of treatment. AIMS To determine the relation between the vacA and the cagA status of H pylori, clinical disease, and treatment outcome. PATIENTS 121 patients with H pylori infection and peptic ulcer disease or functional dyspepsia were treated by quadrupl...

ژورنال: دانشور پزشکی 2013
طباطبایی‌‌پناه, اکرم سادات, اکبرزاده نجار, رضا , خدایی, زهره , قادریان, سید محمدحسین ,

 Background and Objective: Helicobacter pylori (H. pylori) infection is one of the most common gastrointestinal infections worldwide. Infection with H. pylori strains may results in different pathological manifestation and increased oxidative stress lead to a strong inflammatory response in gastric mucosa. There is continuing interest in identifying H. pylori virulence factors that might p...

Journal: :The Journal of clinical investigation 2001
F Tombola L Morbiato G Del Giudice R Rappuoli M Zoratti E Papini

Urease and the cytotoxin VacA are two major virulence factors of the human pathogen Helicobacter pylori, which is responsible for severe gastroduodenal diseases. Diffusion of urea, the substrate of urease, into the stomach is critically required for the survival of infecting H. pylori. We now show that VacA increases the transepithelial flux of urea across model epithelia by inducing an unsatur...

Journal: :Carcinogenesis 2008
Kenny Chitcholtan Mark B Hampton Jacqueline I Keenan

Chronic Helicobacter pylori infection is associated with an increased risk of gastric carcinogenesis. These non-invasive bacteria colonize the gastric mucosa and constitutively shed small outer membrane vesicles (OMV). In this study, we investigated the direct effect of H.pylori OMV on cellular events associated with carcinogenesis. We observed increased micronuclei formation in AGS human gastr...

Journal: :FEMS microbiology letters 2004
Richard H Argent Christine McGarr John C Atherton

Intracellular VacA localises to the vacuolar (late endosome/lysosome) membrane, but little is known about the trafficking of the toxin beyond this region. We show that the Golgi-disturbing agent brefeldin A (BFA) enhances VacA-induced vacuolation of epithelial cells by Helicobacter pylori co-culture and, importantly, BFA treatment induces vacuolation by less toxic forms of VacA. The effect is B...

Journal: :Journal of clinical microbiology 1999
D Domingo T Alarcón N Prieto I Sánchez M López-Brea

Helicobacter pylori is a gram-negative rod associated with gastroduodenal pathologies, such as gastritis, peptic ulcer, and gastric adenocarcinoma. Although most H. pylori infections are clinically silent, the organism is associated with substantial morbidity and mortality. It is unknown why the bacteria are able to produce severe disease in some hosts and be innocuous in others. Different viru...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2002
Bruno Neu Pamela Randlkofer Mathilde Neuhofer Petra Voland Artur Mayerhofer Markus Gerhard Wolfgang Schepp Christian Prinz

Gastric Helicobacter pylori infection may lead to multifocal atrophic corpus gastritis associated with loss of epithelial cells as well as glandular structures. The current work investigated H. pylori effects on cell death of isolated, nontransformed rat parietal cells (PC). Highly enriched rat PC (>97%) were isolated from gastric mucosa and cultured in serum-free medium over 24 h. The cells we...

Journal: :The Journal of Experimental Medicine 2000
Keiji Ogura Shin Maeda Masafumi Nakao Takeshi Watanabe Mayumi Tada Toshimasa Kyutoku Haruhiko Yoshida Yasushi Shiratori Masao Omata

Helicobacter pylori infection induces various gastroduodenal diseases. We examined the role of two genes, vacA and cagE, in the gastric pathogenesis induced by H. pylori using a long-term (62 wk) animal model. Reportedly, both genes are associated with the virulence of H. pylori: vacA encodes vacuolating cytotoxin, and cagE, with other genes in the cag pathogenicity islands, encodes a type IV s...

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