There is an unmet need for high-throughput fabrication techniques for paper-based microanalytical devices, especially in limited resource areas. Fabrication of these devices requires precise and repeatable deposition of hydrophobic materials in a defined pattern to delineate the hydrophilic reaction zones. In this study, we demonstrated a cost- and time-effective method for high-throughput, eas...

BACKGROUND The purpose of this study was to evaluate the reliability, effectiveness, and safety of modified right heart contrast transthoracic echocardiography (cTTE) in comparison with the traditional method. MATERIAL/METHODS We performed a modified right heart cTTE using saline mixed with a small sample of patient's own blood. Samples were agitated with varying intensity. This study protoco...

The hematotoxicity of benzene exposure has been well known for a century. Benzene causes leukocytopenia, thrombocytopenia, pancytopenia, etc. The clinical and hematologic picture of aplastic anemia resulting from benzene exposure is not different from classical aplastic anemia; in some cases, mild bilirubinemia, changes in osmotic fragility, increase in lactic dehydrogenase and fecal urobilinog...

B ILATERAL NEPIIRECTOMY of the dog and rabbit is associated with a hemolytic state as demonstrated by a rapid decline in red blood cell volume in the absence of hemorrhage which, at the same time, is associated with elevation of serum bilirubin ( mainly “indirect” type ) , stool urobilinogen and serum iron, and siderosis of liver, spleen and lymph nodes.”2 While renoprival hemolysis progresses,...

BACKGROUND Large increases of urinary porphobilinogen (PBG) indicate acute porphyria, which may be due to acute intermittent porphyria, variegate porphyria, or hereditary coproporphyria. These conditions are relatively rare but share symptoms with more common conditions, such as acute surgical abdomen, and often must be ruled out rapidly. Reported quantitative methods for PBG measurement are ti...

23 Abstract: The effects of acute GrayanotoxinI (GTX-I) administration on hepatic and renal functions in rats were investigated. GTX-I was administrated to the animals of groups 1, 2 and 3 at a single i.p. dose of 1 mg/kg, 0.5 mg/kg and 0.25 mg/kg respectively, and group 4 (control) received i.p. saline (0.9 %) solution only. One hour following the administration of GTX-I or saline, urine analy...

B ILATERAL NEPIIRECTOMY of the dog and rabbit is associated with a hemolytic state as demonstrated by a rapid decline in red blood cell volume in the absence of hemorrhage which, at the same time, is associated with elevation of serum bilirubin ( mainly “indirect” type ) , stool urobilinogen and serum iron, and siderosis of liver, spleen and lymph nodes.”2 While renoprival hemolysis progresses,...

The need to expand malaria diagnosis capabilities alongside policy requirements for mandatory testing before treatment motivates exploration of noninvasive rapid diagnostic tests (RDTs). We report the outcome of the first cross-sectional, single-blind clinical performance evaluation of a urine malaria test (UMT) for diagnosis of Plasmodium falciparum malaria in febrile patients. Matched urine a...