Amongst the many other chronic complications, diabetes can cause impaired wound healing and, with it, increased morbidity. Up to 25% of all patients with diabetes will develop a foot ulcer and, each year in Australia, approximately 3000 persons with diabetes require amputation secondary to foot ulceration 1. The essential components of diabetic foot ulcer treatment include increasing blood supp...

OBJECTIVE Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulcer healing. RESEARCH DESIGN AND METHODS Ten type 1 diabetic patients with 21...

This issue of Seminars in Vascular Surgery is devoted to the evaluation and management of lower-limb wounds in the vascular surgery patient. In-depth discussions of common clinical conditions are presented on the topics of venous ulcer, diabetic foot infection, peripheral arterial disease (PAD) with tissue loss, and surgical site infection (SSI). The first article by Scalise et al discusses the...

UNLABELLED Amniotic membrane (AM) can promote proper epithelialization with suppression of excessive fibrosis by creating a supportive milieu for regeneration of chronic ulcer bed. OBJECTIVE The objective of this study is to investigate whether AM scaffold can modulate the healing of a wound by promoting tissue reconstruction rather than promoting scar tissue formation. SUBJECTS AND METHODS...

OBJECTIVE To determine which social and clinical factors are associated with healing in patients with venous ulceration. DESIGN Patients were questioned about social factors at their first visit to a community ulcer clinic. They were treated by high compression bandage system and were interviewed again after 12 weeks. SETTING Community leg ulcer clinics held in health centres throughout Riv...

Antibiotics, commonly amoxycillin, tetracycline, metronidazole and clarithromycin, are presently used in combination with anti-ulcer agents such as omeprazole, colloidal bismuth subcitrate, and sucralfate to treat Helicobacter pylori infection in patients with peptic ulcer, and compelling evidence has accumulated that eradication of the organism prevents duodenal ulcer relapse. The latest combi...

OBJECTIVES/HYPOTHESIS Oral ulcers are very common and can compromise the quality of life of patients with pain. The objective of this study was to evaluate mucosal healing with curcumin in an animal oral ulcer model. STUDY DESIGN Experimental study. METHODS Twenty New Zealand white rabbits were used. Round filter paper 6 mm in diameter was soaked with 15 μl 50% acetic acid and applied over ...

The importance of prostaglandin E(2) in various pathophysiological events emphasizes the necessity of understanding the role of PGE synthases (PGESs) in vivo. However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1) to the physiological healing processes of gastric ulcers, or to angiogenesis, which is indispensable to the healing processes. In this report, we...