Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein...

OBJECTIVES Identification of causative agent with estimation of cerebrospinal fluid (CSF) glucose, protein, cells is necessary for accurate diagnosis of meningitis. Unfortunately, even these facilities are not available in many areas. Reagent strips that measure glucose and protein in blood and urine can serve this task but have been used with varying results in the past. This study was carried...

BACKGROUND Tuberculosis kills five lakh patients in India every year, out of which 7-12 % are with meningeal involvement. Delay in its diagnosis and in initiation of treatment results in poor prognosis and sequlae in up to 25% of cases. The aim of the present study is to look for a simple, rapid, cost effective, non-invasive and fairly specific test in differentiating tubercular etiology from o...

ObjectiveThe aim of this study was to assess the clinical utility metagenomic next-generation sequencing (mNGS) on smear-negative extrapulmonary specimens collected in China.MethodsSpecimens were tested by mNGS and other routine tests for tuberculosis (TB). The diagnostic accuracy calculated compared with final diagnosis.ResultsThe sensitivity found be significantly higher than sensitivities TB...

ObjectivesTo evaluate the clinical utility of metagenomic next-generation sequencing (mNGS) for diagnosis central nervous system (CNS) infection in people living with human immunodeficiency virus (PLWH) a real-world situation.MethodsCerebrospinal fluid (CSF) was sent mNGS PLWH who tested negative on all conventional tests but were still suspected to have CNS infection. A retrospective analysis ...