The metabolism of n-tryptophan in man was recently studied by Langner and Berg (l), who found that about one-third to one-half of a 2 gm. dose was excreted unchanged in the urine. Considerable n-kynurenine and traces of indolepyruvic acid and acetyltryptophan were also excreted by their subjecm. Langner and Volkmann (2) found that acetyl-n-tryptophan was poorly absorbed and most of the compound...

Abstract Rauwolfia tetraphylla L., is an important medicinal plant in Apocynaceae family and recognized as alternative source to serpentina terms of anti-hypertensive alkaloid production i.e. reserpine. In view this, the present study conducted estimate reserpine content different parts (leaf, stem root) field grown plants (2 years old), tissue cultured plantlets (R 1 ) (two months old) cell su...

L-Tryptophan (Trp) is an essential amino acid and its deficiency is involved in various pathologies. In this present investigation an attempt was made to study the role of tryptophan and its metabolites in cataract formation in wistar rats. Rats were divided and maintained in 3 groups, Group A--control; Group B--marginal-tryptophan and Group C--Tryptophan-deficient diet for 3 months. Slit lamp ...

The process of induction of tryptophan oxygenase in Pseudomonas acidovorans is typical of many microbial enzyme induction systems, in that it (i) requires cell multiplication and de novo protein synthesis, (ii) is subject to catabolite repression, (iii) results in the formation of a stable enzyme, whose level, upon removal of inducer, is diluted out by cell proliferation, and (iv) exhibits prod...

The in vivo regulation of intermediate reactions in the pathway of tryptophan synthesis in Neurospora crassa was examined in a double mutant (tr-2, tr-3) which lacks the functions of the first and last enzymes in the pathway from chorismic acid to tryptophan. The double mutant can convert anthranilic acid to indole and indole-3-glycerol, and the production of these indolyl compounds by germinat...

Key words rhodium catalysis - C–H functionalization macrocyclic peptides tryptophan-containing

Key words Sc(OTf)3 - aziridine carboxylates ring opening tryptophan derivatives

Avena coleoptiles did not elongate when incubated with tryptophan under sterile conditions. Indole, anthranilic acid, and tryptamine promoted elongation. Under the same conditions, the tissue converted tryptophan-(14)C to IAA-(14)C. More IAA-(14)C was produced from indole-(14)C than from tryptophan-(14)C; however, the free tryptophan content of the tissue was also greatly increased by the indol...

TRAP is an 11 subunit RNA binding protein that regulates expression of genes involved in tryptophan biosynthesis and transport in Bacillus subtilis. TRAP is activated to bind RNA by binding up to 11 molecules of l-tryptophan in pockets formed by adjacent subunits. The precise mechanism by which tryptophan binding activates TRAP is not known. Thr30 is in the tryptophan binding pocket. A TRAP mut...

L-Tryptophan (tryptophan) is an essential amino acid in humans. It has important roles as a precursor of different bioactive compounds. Based on previous studies in which tryptophan has been shown to be present in fresh cherries, the aim of the present work was to analyze the tryptophan content of a Jerte Valley cherry-based product. A previously optimized method of analysis of tryptophan was u...