Tetradentate metalloenediynes with strong imine and weaker thioether coordination serve as a geometrically non-rigid switch to drive thermal Bergman cyclization.

The peroxidation of polyunsaturated fatty acids leads to numerous products, including 4-hydroxynonenal (HNE). That 4-hydroxy-2-alkenal compounds react with sulfhydryl groups of proteins to form thioether adducts possessing a carbonyl function has been established [Schauenstein, E. & Esterbauer, H. (1979) Ciba Found. Symp. 67, 225-244]. Taking advantage of the fact that Raney nickel catalyzes cl...

Galactose oxidase (EC ) is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes. The protein contains an unusual covalent thioether bond between a tyrosine, which acts as a radical center during the two-electron reaction, and a cysteine. The enzyme is produced in a precursor form lacking the thioethe...

The twist–bend nematic (NTB) phase is a liquid crystal (LC) with heliconical structure that typically forms below the temperature of conventional (N) phase. By contrast, direct transition between NTB and isotropic (Iso) phases without intermediation N rarely occurs. Herein, we demonstrate effects linkage type (i.e., methylene, ether, thioether) on typical Iso–N–NTB rare Iso–NTB phase-transition...

Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids.

The final urinary excretion product of selenium detoxification is trimethylselenonium ion. An assay has been developed for the enzyme, S-adenosylmethionine:thioether S-methyltransferase, responsible for this final methylation reaction. This assay employed high pressure liquid chromatography separation and quantitation of the trimethylselenonium ion produced by thioether methyltransferase acting...

Lantibiotics are lanthionine-containing peptide antibiotics. Nisin, encoded by nisA, is a pentacyclic lantibiotic produced by some Lactococcus lactis strains. Its thioether rings are posttranslationally introduced by a membrane-bound enzyme complex. This complex is composed of three enzymes: NisB, which dehydrates serines and threonines; NisC, which couples these dehydrated residues to cysteine...

Cell-free extracts from Escherichia coli cleave the thioether linkage of S-ribosylhomocysteine and generate free homocysteine. Homocysteine was quantitatively recovered from reaction mixtures by ion exchange chromatography on Amberlite CG-120 resin. Free ribose was not a product of this cleavage; however, a compound initially derived from the ribose moiety of S-ribosylhomocysteine has been isol...