Family data teamed with the transmission/disequilibrium test (TDT), which simultaneously evaluates linkage and association, is a powerful means of detecting disease-liability alleles. To increase the information provided by the test, various researchers have proposed TDT-based methods for haplotype transmission. Haplotypes indeed produce more-definitive transmissions than do the alleles compris...

Çalışmanın amacı Türkiye’nin Türk Devletleri Teşkilatı (TDT) asıl üye ülkeleri ve gözlemci ile olan ticaretinde hangi mal gruplarında karşılaştırmalı üstünlüğe sahip olduğunu, ise olmadığını analiz etmektir. 1995-2021 dönemine ait SITC Rev. 3 basamak 1 veri setinin kullanıldığı analizler Açıklanmış Karşılaştırmalı Üstünlükler (AKÜ) yaklaşımına göre yapılmıştır. Elde edilen bulgulara Türkiye Aze...

A new enzyme activity that resembles terminal deoxynucleotidyl transferase (TdT-like activity) was found in rat liver. Upon treatment of rats with a hepatocarcinogen, N-2-fluorenylacetamide, the TdT-like activity increased in parallel with DNA polymerase Ci and 'Y. By phosphocellulose column chromatography, the TdT-like activity was separated from DNA polymerase Ci, fJ, and 'Y. With a poly(dA)-...

Temporal discrimination thresholds (TDT) for recognition of paired sensory (tactile, auditory and visual) stimuli given over a wide range of time intervals were assessed in 44 patients with Parkinson's disease (PD) and 20 age-matched normal subjects. A significant increment in TDT for all three sensory modalities was found in PD patients compared with controls. This abnormality was greatly atte...

Terminal deoxynucleotidyl transferase (TdT)-positive cells in human bone marrow (BM) are a phenotypically inhomogeneous population of precursor cells. In their majority, these TdT+ cells are unambiguously committed to the B lineage, as evidenced by CD19 expression. However, TdT+ precursors that lack CD19 also exist and these may encompass a differentiation potential for the B as well as for oth...

In acute myeloid leukemia (AML), new strategies assess the potential benefit of genetically targeted therapy at diagnosis. This implies waiting for laboratory tests and therefore a delay in initiation of chemotherapy. We studied the impact of time from diagnosis to treatment (TDT) on overall survival, early death, and response rate in a retrospective series of 599 newly diagnosed AML patients t...

A primary xenogeneic culture system has been devised that selectively generates undifferentiated TdT+ lymphoblasts from rat bone marrow under conditions that do not support the growth or maintenance of rat colony-forming unit-spleen (CFU-S) or granulocyte/macrophage colony-forming cells (GM-CFC). The culture system requires a mouse bone marrow feeder layer, and a serum supplement that has marke...

Background: Thalassemia is a genetic disorder of defective hemoglobin synthesis. In transfusion dependent thalassemia (TDT), iron overload caused by repeated blood for long time. This increased deposited in body tissue and may lead to endocrine dysfunction. Objective: To evaluate the relationship between serum ferritin parathyroid dysfunction adult male patients with TDT. Methods: It was cross ...

In this paper, we explored the use of various extra information to improve the performance of spoken document retrieval (SDR). From the speech recognition perspective, we incorporated the acoustic stress and word confusion information into the audio indexing. From the linguistic perspective, we applied the partof-speech information in both the audio indexing and the query representation. From t...

The transmission/disequilibrium test (TDT) [Spielman et al.: Am J Hum Genet 1993;52:506-516] has been postulated as the future of gene mapping for complex diseases, provided one is able to genotype a dense enough map of markers across the genome. Risch and Merikangas [Science 1996;273:1516-1517] suggested a million-marker screen in affected sibpair (ASP) families, demonstrating that the TDT is ...