BACKGROUND Dihydroxyacetone (DHA), a colorless sugar in "sunless" tanning lotions, binds to stratum corneum to form a UV-A-protective brown pigment. Bound DHA polymer is shed faster from hyperproliferative skin sites such as psoriatic plaques. We tested the hypothesis that selective shedding of DHA pigment during psoralen-UV-A (PUVA) treatment of psoriasis may allow higher UV-A doses, thus acce...

Psoralen photochemotherapy [psoralen ultraviolet A (PUVA)] plays an important part in dermatological therapeutics, being an effective and generally safe treatment for psoriasis and other dermatoses. In order to maintain optimal efficacy and safety, guidelines concerning best practice should be available to operators and supervisors. The British Photodermatology Group (BPG) have previously publi...

mucinous material in the dermis. As regards therapy, LM is very dif® cult to treat. Various agents have been tried, including melphalan, prednisone, cyclophosphamide, clorambucil, radiation, PUVA, plasma exchange, 2-chlorodeoxyadenosine, isotretinoin, photophoresis and interferon-a. None of these agents has been universally effective and many are associated with signi® cant toxicity. Our patien...

Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is a low-grade cutaneous lymphoma characterized by skin-homing CD4+ T cells. It is notable for highly symptomatic progressive skin lesions, including patches, plaques, tumors, and erytheroderma, and has a poorer prognosis at later stages. Diagnosis remains difficult owing to MF's nonspecific skin presentation and identification ...

Background: Due to the chronic nature of atopic dermatitis and dependence of most patients to steroids, finding a suitable alternative treatment is important. Objectives: To determine the efficacy of phototherapy in treatment of atopic dermatitis, also to evaluate possible influencing factors in response of patients to psoralen+UVA (PUVA) therapy. Patients and Methods: 13 patients with resistan...

OBJECTIVE To compare the efficacy of narrowband UV-B (TL-01) phototherapy with oral 8-methoxypsoralen photochemotherapy (8-MOP psoralen-UV-A [PUVA]) in patients with chronic plaque psoriasis (CPP). DESIGN Open, randomized, controlled study. SETTING Phototherapy unit in a dermatology hospital. PATIENTS Fifty-four patients with CCP. INTERVENTIONS Patients received whole-body threshold ery...

The use of histone deacetylase inhibitors (HDACI), a promising new class of antineoplastic agents, in combination with cytotoxic agents, such as ionizing radiation and anticancer drugs, has been attracting attention. In this study, we found that sodium butyrate (SB), a widely studied HDACI, remarkably enhanced the cell killing effect of psoralen plus UVA (PUVA) in several cancer cell lines, inc...

Psoralen plus ultraviolet A (PUVA) has immunomodulatory effects through enhancement of Tregactivity, making it a promising steroid-sparing therapy for cutaneous graft versus host disease (GVHD). We performed single-institution, retrospective study 146 patients who underwent an allogenic stem cell transplant (SCT) between 2011-2019, were diagnosed with acute GVHD (aGVHD), and treated at least on...

BACKGROUND There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis. Psoralens are metabolised by cytochrome P450 enzymes (P450), and we hypothesised that variability in cutaneous P450 expression may influence PUVA sensitivity. We previously showed that P450 CYP1B1 was abundantly expressed in hu...