Extracellular-superoxide dismutase (genetic name SOD3) is a secreted anti-oxidative enzyme, and its presence in vascular walls may play an important role in protecting the vascular system against oxidative stress. Oxidative stress has been implicated in the pathogenesis of diabetic retinopathy; therefore, increases in extracellular-superoxide dismutase have been suggested to inhibit the progres...

A common characteristic of familial (fALS) and sporadic amyotrophic lateral sclerosis (sALS) is the accumulation aberrant proteinaceous species in motor neurons spinal cord ALS patients—including aggregates human superoxide dismutase 1 (hSOD1). hSOD1 an enzyme that occurs as a stable dimeric protein with several post-translational modifications such formation intramolecular disulfide bond acqui...